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Proline/Serine Rich Coiled Coil protein 1 (PSRC1)

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DDA3; Differential Display And Activated By p53

Proline/Serine Rich Coiled Coil protein 1 (PSRC1)
CCC M069
HGNC 24472
MGI 1913099
PubMed 12427559
RGD 1585037
UniProt Q6PGN9
Wiki PSRC1
PSRC1 encodes a proline-rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. Alternatively spliced transcript variants encoding different isoforms have been described.
The deduced 333-amino acid protein shares 68.2% identity with mouse Dda3, with highest conservation in the N-terminal half. Both mouse and human DDA3 are rich in serine and proline and contain a coiled-coil domain, and 3 of 6 PxxP motifs in mouse Dda3 are conserved in human DDA3. PCR analysis revealed variable DDA3 expression in all human tissues examined except skeletal muscle. Highest expression was detected in fetal thymus and adult brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM069Hu01 Recombinant Proline/Serine Rich Coiled Coil protein 1 (PSRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM069Hu01 Polyclonal Antibody to Proline/Serine Rich Coiled Coil protein 1 (PSRC1) WB; IHC; ICC; IP.
MAM069Hu21 Monoclonal Antibody to Proline/Serine Rich Coiled Coil protein 1 (PSRC1) WB; IHC; ICC; IP.
Assay Kits SEM069Hu ELISA Kit for Proline/Serine Rich Coiled Coil protein 1 (PSRC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proline/Serine Rich Coiled Coil protein 1 (PSRC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proline/Serine Rich Coiled Coil protein 1 (PSRC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proline/Serine Rich Coiled Coil protein 1 (PSRC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proline/Serine Rich Coiled Coil protein 1 (PSRC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proline/Serine Rich Coiled Coil protein 1 (PSRC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proline/Serine Rich Coiled Coil protein 1 (PSRC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proline/Serine Rich Coiled Coil protein 1 (PSRC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proline/Serine Rich Coiled Coil protein 1 (PSRC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proline/Serine Rich Coiled Coil protein 1 (PSRC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proline/Serine Rich Coiled Coil protein 1 (PSRC1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of human and mouse DDA3 genes."Biochim. Biophys. Acta 1579:214-218(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement."J. Cell Biol. 181:255-267(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3."Cell Cycle 8:3165-3171(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]