Steroid 5 Alpha Reductase 1 (SRD5a1)

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3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 1

Steroid 5 Alpha Reductase 1 (SRD5a1)
SRD5a1 isozyme is not detectable in the fetus, is transiently expressed in newborn skin and scalp, and is permanently expressed in skin from the time of puberty. There was no qualitative difference in 5-alpha-reductase type 1 expression between adult balding versus nonbalding scalp. The type 2 isozyme was transiently expressed in skin and scalp of newborns. Type 2 is the predominant isozyme detectable in fetal genital skin, in male accessory sex organs, and in the prostate, including benign prostatic hyperplasia and prostate adenocarcinoma tissues. These results were considered consistent with 5-alpha-reductase type 1 being responsible for the virilization in type 2-deficient subjects during puberty and suggested that the type 2 isozyme may be an initiating factor in the development of male pattern baldness.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) Polyclonal Antibody Customized Service Offer
Assay Kits SEM286Hu ELISA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM286Mu01 Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) Positive Control; Immunogen; SDS-PAGE; WB.
RPM286Mu02 Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) Positive Control; Immunogen; SDS-PAGE; WB.
APM286Mu01 Active Steroid 5 Alpha Reductase 1 (SRD5a1) Cell culture; Activity Assays.
Antibodies PAM286Mu01 Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) WB; IHC; ICC; IP.
PAM286Mu02 Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) WB; IHC; ICC; IP.
Assay Kits SEM286Mu ELISA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM286Ra01 Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM286Ra01 Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) WB; IHC; ICC; IP.
MAM286Ra21 Monoclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) WB; IHC; ICC; IP.
Assay Kits SEM286Ra ELISA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases."Proc. Natl. Acad. Sci. U.S.A. 87:3640-3644(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue."Genomics 11:1102-1112(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8."Pflugers Arch. 442:R187-R189(2001) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]