Sialyltransferase 1 (SIAT1)

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CD75; ST6GAL1; ST6Gal I; ST6GalI; B-cell antigen CD75; Beta-galactoside alpha-2,6-sialyltransferase 1; ST6 Beta Galactosamide Alpha-2,6-Sialyltranferase 1

Sialyltransferase 1 (SIAT1)
SIAT1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally found in the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found for this gene.A 4.7-kb ST6N transcript was expressed in nearly all tissues examined, with highest expression in liver, followed by kidney, spleen, thymus, prostate, and peripheral blood leukocytes. Several smaller transcripts were also detected in liver. Little to no expression was detected in pancreas, testis, and colon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialyltransferase 1 (SIAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialyltransferase 1 (SIAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialyltransferase 1 (SIAT1) Polyclonal Antibody Customized Service Offer
Assay Kits SEM299Hu ELISA Kit for Sialyltransferase 1 (SIAT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialyltransferase 1 (SIAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialyltransferase 1 (SIAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialyltransferase 1 (SIAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialyltransferase 1 (SIAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialyltransferase 1 (SIAT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialyltransferase 1 (SIAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialyltransferase 1 (SIAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialyltransferase 1 (SIAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialyltransferase 1 (SIAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialyltransferase 1 (SIAT1) ELISA Kit Customized Service Offer
  1. "Complete cDNA sequence encoding human beta-galactoside alpha-2,6-sialyltransferase."Nucleic Acids Res. 18:667-667(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The B cell antigen CD75 is a cell surface sialyltransferase."J. Exp. Med. 172:641-643(1990) [PubMed] [Europe PMC] [Abstract]
  3. "The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase."J. Cell Biol. 116:423-435(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation and characterization of a partial cDNA for a human sialyltransferase."Biochem. Biophys. Res. Commun. 164:225-232(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Universal phosphatase-coupled glycosyltransferase assay."Glycobiology 21:727-733(2011) [PubMed] [Europe PMC] [Abstract]
  11. "The structure of human alpha-2,6-sialyltransferase reveals the binding mode of complex glycans."Acta Crystallogr. D 69:1826-1838(2013) [PubMed] [Europe PMC] [Abstract]