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RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon)

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Baron; Rundataxin; Beclin-1 associated RUN domain containing protein

RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon)
CCC M905
HGNC 28991
MGI 1915160
PubMed 20943950
RGD 1305422
UniProt Q92622
Mouse Rubicon coimmunoprecipitated with endogenous beclin-1 (BECN1) and Vps34 (PIK3C3), which are essential components of a protein complex that regulates autophagy. Mutation analysis revealed that the central coiled-coil domains of Rubicon were required for the interaction of Rubicon with beclin-1 and Vps34. Gel filtration experiments revealed that endogenous Vps34, beclin-1, Atg14, and Rubicon coeluted in a complex of over 700 kD. However, immunoprecipitation analysis showed that Atg14 and Rubicon did not always coimmunoprecipitate in the same complex. Knockdown of Rubicon via small interfering RNA enhanced the autophagy-mediated clearance of a test substrate. Rubicon specifically inhibited the kinase activity of human VPS3

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Polyclonal Antibody Customized Service Offer
Assay Kits SEM905Hu ELISA Kit for RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Polyclonal Antibody Customized Service Offer
Assay Kits SEM905Mu ELISA Kit for RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Polyclonal Antibody Customized Service Offer
Assay Kits SEM905Ra ELISA Kit for RUN Domain And Cysteine Rich Domain Containing, Beclin 1 Interacting Protein (Rubicon) Enzyme-linked immunosorbent assay for Antigen Detection.
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  6. "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages."Nat. Cell Biol. 11:385-396(2009) [PubMed] [Europe PMC] [Abstract]
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  8. "Rundataxin, a novel protein with RUN and diacylglycerol binding domains, is mutant in a new recessive ataxia."Brain 133:2439-2447(2010) [PubMed] [Europe PMC] [Abstract]