Zinc Finger Protein 649 (ZNF649)
ZNF649 encodes a deduced 505-amino acid protein that contains an N-terminal Kruppel-associated box (KRAB) belonging to the classic KRAB-AB box, and 10 C2H2 zinc finger motifs that extend to the end of the protein sequence. Northern blot analysis of multiple human tissues detected expression of a 3.2-kb ZNF649 transcript in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas; in adult tissues, the transcript was detected predominantly in heart, skeletal muscle, and brain, and at lower levels in other tissues. A GFP-ZNF649 fusion protein localized primarily in the nucleus of COS-7 cells.ZNF649 can suppress the transcriptional activities of SRE and AP1 transcription factors. Deletion analysis with truncated proteins indicated that the KRAB domain is required for the repressive activity of ZNF649.

Organism species: Homo sapiens (Human)

Proteins n/a Recombinant Zinc Finger Protein 649 (ZNF649) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 649 (ZNF649) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 649 (ZNF649) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 649 (ZNF649) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 649 (ZNF649) ELISA Kit Customized Service Offer
  1. "ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor."Biochem. Biophys. Res. Commun. 333:206-215(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]