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RPRM is induced following x-irradiation in a p53-dependent manner and is a downstream mediator of p53 action. Overexpression of RPRM in HeLa cells by transfection resulted in G2 arrest of the cell cycle by inhibiting both CDC2 activity and nuclear translocation of the CDC2-cyclin B1 (CCNB1) complex.Using a differential display screening approach on mouse embryonal fibroblasts to identify genes that are induced by p53 following x-irradiation, Ohki et al. (2000) identified one, which they termed Reprimo, that is involved in cell cycle regulation. Ohki et al. (2000) cloned mouse and human Reprimo cDNAs, which encode deduced 109-amino acid proteins sharing 98% sequence identity. The Reprimo protein is N-glycosylated and localizes to the cytoplasm.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Reprimo (RPRM) | Recombinant Protein Customized Service Offer |
| Antibodies | PAN346Hu01 | Polyclonal Antibody to Reprimo (RPRM) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Reprimo (RPRM) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Reprimo (RPRM) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Reprimo (RPRM) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Reprimo (RPRM) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Reprimo (RPRM) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Reprimo (RPRM) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Reprimo (RPRM) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPN346Ra01 | Recombinant Reprimo (RPRM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPN346Ra02 | Recombinant Reprimo (RPRM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAN346Ra01 | Polyclonal Antibody to Reprimo (RPRM) | WB; IHC; ICC; IP. |
| LAN346Ra81 | FITC-Linked Polyclonal Antibody to Reprimo (RPRM) | WB; IHC; ICC; IF. | |
| LAN346Ra71 | Biotin-Linked Polyclonal Antibody to Reprimo (RPRM) | WB; IHC; ICC. | |
| PAN346Ra02 | Polyclonal Antibody to Reprimo (RPRM) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Reprimo (RPRM) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Reprimo (RPRM) | ELISA Kit Customized Service Offer |
- "Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase."J. Biol. Chem. 275:22627-22630(2000) [PubMed] [Europe PMC] [Abstract]
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- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]