PHD Finger Protein 21A (PHF21A)

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BHC80a; BRAF35-HDAC complex protein BHC80

PHD Finger Protein 21A (PHF21A)
BHC80 is a component of a BRAF35/histone deacetylase (HDAC) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS).The deduced 635-amino acid protein contains a PHD-type zinc finger. RT-PCR ELISA detected intermediate expression in all tissues and specific brain regions examined. The 634-amino acid BHC80 protein contains an N-terminal leucine zipper, a PHD zinc-finger domain most similar to that of the MI2 protein, and a C-terminal leucine zipper. RT-PCR detected tissue-specific expression, with the highest level in brain. In contrast to BRAF35, overexpression of transfected BHC80 in human embryonic kidney cells completely abrogated RE1-dependent transcriptional repression.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant PHD Finger Protein 21A (PHF21A)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to PHD Finger Protein 21A (PHF21A)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to PHD Finger Protein 21A (PHF21A)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for PHD Finger Protein 21A (PHF21A)CLIA Kit Customized Service Offer
n/aELISA Kit for PHD Finger Protein 21A (PHF21A)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant PHD Finger Protein 21A (PHF21A)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to PHD Finger Protein 21A (PHF21A)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to PHD Finger Protein 21A (PHF21A)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for PHD Finger Protein 21A (PHF21A)CLIA Kit Customized Service Offer
n/aELISA Kit for PHD Finger Protein 21A (PHF21A)ELISA Kit Customized Service Offer
  1. "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes."Proc. Natl. Acad. Sci. U.S.A. 99:7420-7425(2002) [PubMed] [Europe PMC] [Abstract]
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  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression."Biochem. Biophys. Res. Commun. 322:601-608(2004) [PubMed] [Europe PMC] [Abstract]
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  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the PHD domain in PHD finger protein 21A."Submitted (MAR-2008) to the PDB data bank