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Zinc Finger Protein 436 (ZNF436)

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Zfp46

Zinc Finger Protein 436 (ZNF436)
CCC N517
HGNC 20814
MGI 99192
PubMed 11214970
RGD 1310584
UniProt Q9C0F3
Wiki ZNF436
ZNF436 gene contains 3 exons and spans approximately 8.4 kb.ZNF436 encodes a predicted 470-amino acid protein with an N-terminal KRAB-A box, which is conserved across different species from rat to human, and 12 C-terminal C2H2 zinc fingers. RT-PCR analysis detected ZNF436 expression in all fetal tissues examined, with highest levels in brain and heart. Fluorescence studies localized the ZNF436 protein to the nucleus and cytoplasm.
Overexpression of ZNF436 in COS-7 cells strongly repressed transcription mediated by the serum response element (SRE) and the AP1 promoter. The authors suggested that ZNF436 may act as a negative regulator in gene transcription mediated by the MAPK signaling pathways.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 436 (ZNF436) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 436 (ZNF436) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 436 (ZNF436) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 436 (ZNF436) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 436 (ZNF436) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 436 (ZNF436) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 436 (ZNF436) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 436 (ZNF436) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 436 (ZNF436) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 436 (ZNF436) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 436 (ZNF436) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 436 (ZNF436) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 436 (ZNF436) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 436 (ZNF436) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 436 (ZNF436) ELISA Kit Customized Service Offer
  1. "A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE."Mol. Biol. Rep. 33:287-294(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]