Riboflavin Transporter 2 (RFT2)

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SLC52A3; C20orf54; HRFT2; RFVT3; Solute carrier family 52, riboflavin transporter, member 3

Riboflavin Transporter 2 (RFT2)
Biochemical characterization revealed that riboflavin uptake by rat Rft2 was saturable and Na(+) independent, with a pH optimum between 5 and 6. Riboflavin appeared to be the primary molecule transported by Rft2. Riboflavin transport could be competitively inhibited by the riboflavin derivatives lumiflavin, flavin mononucleotide, and flavin adenine dinucleotide, and to a lesser extent by alloxazine and the organic cation amiloride, but not by D-ribose or organic anions. The deduced 469-amino acid protein shares 83% similarity with rat Rft2, which contains 11 potential membrane-spanning domains and a putative N-glycosylation site. Northern blot analysis of rat tissues showed highest Rft2 expression in jejunum, ileum, and testis, with lower expression in lung, kidney, stomach, and colon.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Riboflavin Transporter 2 (RFT2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Riboflavin Transporter 2 (RFT2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Riboflavin Transporter 2 (RFT2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Riboflavin Transporter 2 (RFT2)CLIA Kit Customized Service Offer
n/aELISA Kit for Riboflavin Transporter 2 (RFT2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Riboflavin Transporter 2 (RFT2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Riboflavin Transporter 2 (RFT2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Riboflavin Transporter 2 (RFT2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Riboflavin Transporter 2 (RFT2)CLIA Kit Customized Service Offer
n/aELISA Kit for Riboflavin Transporter 2 (RFT2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Riboflavin Transporter 2 (RFT2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Riboflavin Transporter 2 (RFT2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Riboflavin Transporter 2 (RFT2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Riboflavin Transporter 2 (RFT2)CLIA Kit Customized Service Offer
n/aELISA Kit for Riboflavin Transporter 2 (RFT2)ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and functional characterization of rat riboflavin transporter 2."J. Biochem. 145:437-443(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain."J. Nutr. 140:1220-1226(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Role of cysteine residues in cell surface expression of the human riboflavin transporter-2 (hRFT2) in intestinal epithelial cells."Am. J. Physiol. 301:G100-G109(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment."J. Inherit. Metab. Dis. 34:159-164(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Functional involvement of RFVT3/SLC52A3 in intestinal riboflavin absorption."Am. J. Physiol. 306:G102-G110(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Brown-Vialetto-Van Laere syndrome, a ponto-bulbar palsy with deafness, is caused by mutations in c20orf54."Am. J. Hum. Genet. 86:485-489(2010) [PubMed] [Europe PMC] [Abstract]