Vacuolar Protein Sorting 35 (VPS35)

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MEM3; Maternal-embryonic 3; Vesicle protein sorting 35; Vacuolar protein sorting-associated protein 35

Vacuolar Protein Sorting 35 (VPS35)
VPS35 is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. The SSEC-26 transcript was abundant in the unfertilized egg and also actively transcribed from the newly formed zygotic genome. On the basis of its expression in eggs and embryos, this mouse gene was named Mem3 (maternal-embryonic-3). The deduced amino acid sequence of Mem3 resembles that of the yeast VPS35 protein in 2 separate domains.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Vacuolar Protein Sorting 35 (VPS35)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Vacuolar Protein Sorting 35 (VPS35)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Vacuolar Protein Sorting 35 (VPS35)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Vacuolar Protein Sorting 35 (VPS35)CLIA Kit Customized Service Offer
n/aELISA Kit for Vacuolar Protein Sorting 35 (VPS35)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Vacuolar Protein Sorting 35 (VPS35)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Vacuolar Protein Sorting 35 (VPS35)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Vacuolar Protein Sorting 35 (VPS35)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Vacuolar Protein Sorting 35 (VPS35)CLIA Kit Customized Service Offer
n/aELISA Kit for Vacuolar Protein Sorting 35 (VPS35)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Vacuolar Protein Sorting 35 (VPS35)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Vacuolar Protein Sorting 35 (VPS35)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Vacuolar Protein Sorting 35 (VPS35)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Vacuolar Protein Sorting 35 (VPS35)CLIA Kit Customized Service Offer
n/aELISA Kit for Vacuolar Protein Sorting 35 (VPS35)ELISA Kit Customized Service Offer
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  22. "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."Neuron 77:425-439(2013) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  25. "Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation."Curr. Biol. 24:1670-1676(2014) [PubMed] [Europe PMC] [Abstract]
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