RAD51 Homolog (RAD51)

[Edit]

RAD51A; RECA; HsRad51; BRCC5; BRCA1/BRCA2-Containing Complex Subunit 5; DNA repair protein RAD51 homolog 1

RAD51 Homolog (RAD51)
RAD51 is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPP750Hu01Recombinant RAD51 Homolog (RAD51)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAP750Hu01Polyclonal Antibody to RAD51 Homolog (RAD51)WB, ICC, IHC-P, IHC-F, ELISA
MAP750Hu21Monoclonal Antibody to RAD51 Homolog (RAD51)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEP750HuELISA Kit for RAD51 Homolog (RAD51)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant RAD51 Homolog (RAD51)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to RAD51 Homolog (RAD51)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to RAD51 Homolog (RAD51)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for RAD51 Homolog (RAD51)CLIA Kit Customized Service Offer
n/aELISA Kit for RAD51 Homolog (RAD51)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant RAD51 Homolog (RAD51)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to RAD51 Homolog (RAD51)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to RAD51 Homolog (RAD51)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for RAD51 Homolog (RAD51)CLIA Kit Customized Service Offer
n/aELISA Kit for RAD51 Homolog (RAD51)ELISA Kit Customized Service Offer
  1. "Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA."Nat. Genet. 4:239-243(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and sequence of the human RecA-like gene cDNA."Nucleic Acids Res. 21:1665-1665(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 loss of heterozygosity (LOH)."Cancer Res. 59:4564-4569(1999) [PubMed] [Europe PMC] [Abstract]
  4. "A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers."Cancer Epidemiol. Biomarkers Prev. 10:955-960(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a novel human Rad51 variant that promotes DNA strand exchange."Nucleic Acids Res. 36:3226-3234(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA."EMBO J. 13:5764-5771(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Interaction of human recombination proteins Rad51 and Rad54."Nucleic Acids Res. 25:4106-4110(1997) [PubMed] [Europe PMC] [Abstract]
  11. "A novel nucleic acid-binding protein that interacts with human rad51 recombinase."Nucleic Acids Res. 25:4946-4953(1997) [PubMed] [Europe PMC] [Abstract]
  12. "RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein."Proc. Natl. Acad. Sci. U.S.A. 94:6927-6932(1997) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of Rad51 function by c-Abl in response to DNA damage."J. Biol. Chem. 273:3799-3802(1998) [PubMed] [Europe PMC] [Abstract]
  14. "A novel human Rad54 homologue, Rad54B, associates with Rad51."J. Biol. Chem. 275:26316-26321(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Homologous DNA pairing by human recombination factors Rad51 and Rad54."J. Biol. Chem. 277:42790-42794(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells."Nucleic Acids Res. 30:1009-1015(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro."J. Biol. Chem. 278:2469-2478(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51."J. Cell. Biochem. 96:1095-1109(2005) [PubMed] [Europe PMC] [Abstract]
  19. "The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair."Nat. Cell Biol. 7:195-201(2005) [PubMed] [Europe PMC] [Abstract]
  20. "RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51."Nucleic Acids Res. 34:5081-5092(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Single-stranded DNA-binding protein hSSB1 is critical for genomic stability."Nature 453:677-681(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C."J. Biol. Chem. 284:31945-31952(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity."J. Biol. Chem. 285:15739-15745(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome."J. Biol. Chem. 285:18984-18990(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Regulation of DNA repair through desumoylation and sumoylation of replication protein A complex."Mol. Cell 39:333-345(2010) [PubMed] [Europe PMC] [Abstract]
  26. "RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase."Mol. Cell. Biol. 30:2460-2472(2010) [PubMed] [Europe PMC] [Abstract]
  27. "A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination."Nat. Struct. Mol. Biol. 17:365-372(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination."Nat. Struct. Mol. Biol. 17:1247-1254(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Homologous recombination proteins are associated with centrosomes and are required for mitotic stability."Exp. Cell Res. 317:1203-1213(2011) [PubMed] [Europe PMC] [Abstract]
  30. "The role of human SWI5-MEI5 complex in homologous recombination repair."J. Biol. Chem. 286:9888-9893(2011) [PubMed] [Europe PMC] [Abstract]
  31. "hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair."J. Biol. Chem. 286:41758-41766(2011) [PubMed] [Europe PMC] [Abstract]
  32. "RAD51 haploinsufficiency causes congenital mirror movements in humans." Am. J. Hum. Genet. 90:301-307(2012) [PubMed] [Europe PMC] [Abstract]
  33. "Inhibition of homologous recombination by the PCNA-interacting protein PARI."Mol. Cell 45:75-86(2012) [PubMed] [Europe PMC] [Abstract]
  34. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  35. "Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair."Oncogene 33:4803-4812(2014) [PubMed] [Europe PMC] [Abstract]
  36. "FIGNL1-containing protein complex is required for efficient homologous recombination repair."Proc. Natl. Acad. Sci. U.S.A. 110:10640-10645(2013) [PubMed] [Europe PMC] [Abstract]
  37. "Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair."Proc. Natl. Acad. Sci. U.S.A. 110:10646-10651(2013) [PubMed] [Europe PMC] [Abstract]
  38. "Homologous-recombination-deficient tumours are dependent on Poltheta-mediated repair."Nature 518:258-262(2015) [PubMed] [Europe PMC] [Abstract]
  39. "The N-terminal domain of the human Rad51 protein binds DNA: structure and a DNA binding surface as revealed by NMR."J. Mol. Biol. 290:495-504(1999) [PubMed] [Europe PMC] [Abstract]
  40. "Insights into DNA recombination from the structure of a RAD51-BRCA2 complex."Nature 420:287-293(2002) [PubMed] [Europe PMC] [Abstract]
  41. "Identification of Rad51 alteration in patients with bilateral breast cancer."J. Hum. Genet. 45:133-137(2000) [PubMed] [Europe PMC] [Abstract]