Keratin 83 (KRT83)

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KRTHB3; K83; Hb-3; Keratin,Hair,Basic 3; Hard Keratin Type II 3; Keratin, type II cuticular Hb3

Keratin 83 (KRT83)
KRT83 is a member of the keratin gene family. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. The predicted protein has 494 amino acids. The amino acid sequences of HB1, HB3, HB5, and HB6 are extremely conserved in the alpha-helical, N-terminal, and proximal C-terminal domains. HB3 is more closely related to HB1 and HB6 than to HB5. In situ hybridization studies demonstrated that type II keratin genes are sequentially activated in the hair follicle in the following order: HB5--(HB1, HB3)--HB6. Both HB1 and HB3 mRNA syntheses begin 10 to 15 cell layers above the apex of the dermal papilla and end abruptly in the middle of the cortex.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Keratin 83 (KRT83)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Keratin 83 (KRT83)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Keratin 83 (KRT83)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Keratin 83 (KRT83)CLIA Kit Customized Service Offer
n/aELISA Kit for Keratin 83 (KRT83)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Keratin 83 (KRT83)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Keratin 83 (KRT83)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Keratin 83 (KRT83)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Keratin 83 (KRT83)CLIA Kit Customized Service Offer
n/aELISA Kit for Keratin 83 (KRT83)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Keratin 83 (KRT83)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Keratin 83 (KRT83)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Keratin 83 (KRT83)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Keratin 83 (KRT83)CLIA Kit Customized Service Offer
n/aELISA Kit for Keratin 83 (KRT83)ELISA Kit Customized Service Offer
  1. "Sequences and differential expression of three novel human type-II hair keratins."Differentiation 61:187-194(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of a 300 kbp region of human DNA containing the type II hair keratin."J. Invest. Dermatol. 114:464-472(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A missense mutation in the type II hair keratin hHb3 is associated with monilethrix."J. Med. Genet. 42:E19-E19(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Novel KRT83 and KRT86 mutations associated with monilethrix."Exp. Dermatol. 24:222-224(2015) [PubMed] [Europe PMC] [Abstract]