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Dihydrodiol Dehydrogenase 2 (DDH2)

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AKR1C2; DD; BABP; DD2; HAKRD; MCDR2; Aldo-Keto Reductase Family 1,Member C2; Bile Acid Binding Protein; 3-Alpha Hydroxysteroid Dehydrogenase Type III

Dihydrodiol Dehydrogenase 2 (DDH2)
CCC Q200
HGNC 385
MGI 1924587
PubMed 17661040
RGD 1311841
UniProt P52895
Dihydrodiol dehydrogenase (DD; EC 1.3.1.20), a member of the aldo-oxo reductase (AKR) superfamily, catalyzes the NADP-linked oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols. DDH2 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ200Hu01 Recombinant Dihydrodiol Dehydrogenase 2 (DDH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAQ200Hu01 Polyclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) WB; IHC; ICC; IP.
MAQ200Hu21 Monoclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) WB; IHC; ICC; IP.
Assay Kits SEQ200Hu ELISA Kit for Dihydrodiol Dehydrogenase 2 (DDH2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dihydrodiol Dehydrogenase 2 (DDH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dihydrodiol Dehydrogenase 2 (DDH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dihydrodiol Dehydrogenase 2 (DDH2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dihydrodiol Dehydrogenase 2 (DDH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dihydrodiol Dehydrogenase 2 (DDH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dihydrodiol Dehydrogenase 2 (DDH2) ELISA Kit Customized Service Offer
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  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells."Biochem. J. 313:373-376(1996) [PubMed] [Europe PMC] [Abstract]
  11. "cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family."J. Biol. Chem. 268:10448-10457(1993) [PubMed] [Europe PMC] [Abstract]
  12. "Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation."Am. J. Hum. Genet. 89:201-218(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate."Biochemistry 40:10161-10168(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution."J. Biol. Chem. 276:42091-42098(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an 'induced-fit' mechanism and a conserved basic motif involved in the binding of androgen."Protein Sci. 14:1485-1497(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme."J. Mol. Biol. 364:747-763(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding."J. Mol. Biol. 369:525-540(2007) [PubMed] [Europe PMC] [Abstract]