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C-Type Lectin Domain Family 6, Member A (CLEC6A)

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CLECSF10; Dectin-2; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2

C-Type Lectin Domain Family 6, Member A (CLEC6A)
CCC Q430
HGNC 14556
MGI 1861231
PubMed 23573288
UniProt Q6EIG7
CLEC6A is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain.
The predicted 209-amino acid protein shares 68% identity with mouse dectin-2. It has a short N-terminal cytoplasmic region that lacks a tyrosine-based signaling motif, a 27-residue transmembrane domain with a charged arginine, and a C-terminal extracellular portion with 6 cysteines predicted to form a carbohydrate recognition domain. RT-PCR analysis revealed strong expression in lung and weak expression in spleen, lymph node, and blood leukocytes. Among in vitro-generated dendritic cells (DCs), expression of dectin-2 was strongest in immature Langerhans cell (LC)-type DCs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Type Lectin Domain Family 6, Member A (CLEC6A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Type Lectin Domain Family 6, Member A (CLEC6A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Type Lectin Domain Family 6, Member A (CLEC6A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Type Lectin Domain Family 6, Member A (CLEC6A) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Type Lectin Domain Family 6, Member A (CLEC6A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Type Lectin Domain Family 6, Member A (CLEC6A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Type Lectin Domain Family 6, Member A (CLEC6A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Type Lectin Domain Family 6, Member A (CLEC6A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Type Lectin Domain Family 6, Member A (CLEC6A) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Type Lectin Domain Family 6, Member A (CLEC6A) ELISA Kit Customized Service Offer
  1. "Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex."Immunogenetics 56:506-517(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of human dectin-2."J. Invest. Dermatol. 122:1522-1524(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2."Exp. Dermatol. 14:281-288(2005) [PubMed] [Europe PMC] [Abstract]