Post GPI Attachment To Proteins 2 (PGAP2)

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FRAG1; CWH43-N; FGF Receptor Activating Protein 1; Cell Wall Biogenesis 43 N-Terminal Homolog

Post GPI Attachment To Proteins 2 (PGAP2)
Biosynthesis of glycosylphosphatidylinositol-anchored proteins in the ER has been extensively studied, whereas the molecular events during the transport of GPI-APs from the ER to the cell surface are poorly understood. PGAP2 encoded a Golgi/ER-resident membrane protein. The low surface expression of GPI-APs was due to their secretion into the culture medium. GPI-APs were modified/cleaved by two reaction steps in the mutant cells. First, the GPI anchor was converted to lyso-GPI before exiting the trans-Golgi network. Second, lyso-GPI-APs were cleaved by a phospholipase D after transport to the plasma membrane.PGAP2 deficiency caused transport to the cell surface of lyso-GPI-APs that were sensitive to a phospholipase D. PGAP2 is involved in the processing of GPI-APs required for their stable expression at the cell surface.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Post GPI Attachment To Proteins 2 (PGAP2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Post GPI Attachment To Proteins 2 (PGAP2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Post GPI Attachment To Proteins 2 (PGAP2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Post GPI Attachment To Proteins 2 (PGAP2)CLIA Kit Customized Service Offer
n/aELISA Kit for Post GPI Attachment To Proteins 2 (PGAP2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Post GPI Attachment To Proteins 2 (PGAP2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Post GPI Attachment To Proteins 2 (PGAP2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Post GPI Attachment To Proteins 2 (PGAP2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Post GPI Attachment To Proteins 2 (PGAP2)CLIA Kit Customized Service Offer
n/aELISA Kit for Post GPI Attachment To Proteins 2 (PGAP2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Post GPI Attachment To Proteins 2 (PGAP2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Post GPI Attachment To Proteins 2 (PGAP2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Post GPI Attachment To Proteins 2 (PGAP2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Post GPI Attachment To Proteins 2 (PGAP2)CLIA Kit Customized Service Offer
n/aELISA Kit for Post GPI Attachment To Proteins 2 (PGAP2)ELISA Kit Customized Service Offer
  1. "Human FRAG1 encodes a novel membrane-spanning protein that localizes to chromosome 11p15.5, a region of frequent loss of heterozygosity in cancer."Genomics 62:59-66(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Hypomorphic mutations in PGAP2, encoding a GPI-anchor-remodeling protein, cause autosomal-recessive intellectual disability."Am. J. Hum. Genet. 92:575-583(2013) [PubMed] [Europe PMC] [Abstract]
  7. "PGAP2 mutations, affecting the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation syndrome."Am. J. Hum. Genet. 92:584-589(2013) [PubMed] [Europe PMC] [Abstract]