UBX Domain Protein 1 (UBXN1)

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UBXD10; SAKS1; SAPK Substrate Protein 1; UBA/UBX 33.3 kDa protein

UBX Domain Protein 1 (UBXN1)
The availability of the human and mouse genome sequences has allowed the identification and comparison of their respective degradomes--the complete repertoire of proteases that are produced by these organisms.
UBXN1 contains a ubiquitin-associated (UBA) motif, recognizes autoubiquitinated BRCA1. This occurs through a bipartite interaction in which the UBA domain of UBXN1 binds K6-linked polyubiquitin chains conjugated to BRCA1 while the C-terminal sequences of UBXN1 bind the BRCA1/BARD1 heterodimer in a ubiquitin-independent fashion. Significantly, the E3 ligase activity of BRCA1/BARD1 is dramatically reduced in the presence of UBXN1, suggesting that UBXN1 regulates the enzymatic function of BRCA1 in a manner that is dependent on its ubiquitination status.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant UBX Domain Protein 1 (UBXN1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to UBX Domain Protein 1 (UBXN1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to UBX Domain Protein 1 (UBXN1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for UBX Domain Protein 1 (UBXN1)CLIA Kit Customized Service Offer
n/aELISA Kit for UBX Domain Protein 1 (UBXN1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant UBX Domain Protein 1 (UBXN1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to UBX Domain Protein 1 (UBXN1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to UBX Domain Protein 1 (UBXN1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for UBX Domain Protein 1 (UBXN1)CLIA Kit Customized Service Offer
n/aELISA Kit for UBX Domain Protein 1 (UBXN1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant UBX Domain Protein 1 (UBXN1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to UBX Domain Protein 1 (UBXN1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to UBX Domain Protein 1 (UBXN1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for UBX Domain Protein 1 (UBXN1)CLIA Kit Customized Service Offer
n/aELISA Kit for UBX Domain Protein 1 (UBXN1)ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs."Biochem. J. 384:391-400(2004) [PubMed] [Europe PMC] [Abstract]