Intraflagellar Transport Protein 140 (IFT140)

[Edit]

WDTC2; MZSDS; WD and tetratricopeptide repeats protein 2

Intraflagellar Transport Protein 140 (IFT140)
IFT140 Contains 9 TPR repeats.Contains 5 WD repeats.WD-repeat-containing proteins are those that contain 4 or more copies of the WD-repeat, a sequence motif approximately 31 amino acids long, that encodes a structural repeat. This repeat is described by the following profile, where x is ANY amino acid. By clicking on each high-lighted character you will obtain the distribution of amino acids found at that position of the repeat among an aligned set of WD-repeat containing proteins. The tertiary structure of only one member of this family has been determined, that of the G protein beta subunit, which contains 7 WD-repeats. Each of the 7 repeats folds into a small antiparallel beta-sheet. The over-lines above indicate the position of these strands, with "a" being the strand closest to the central pore and "d" at the external surface of the folded protein.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Intraflagellar Transport Protein 140 (IFT140)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Intraflagellar Transport Protein 140 (IFT140)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Intraflagellar Transport Protein 140 (IFT140)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Intraflagellar Transport Protein 140 (IFT140)CLIA Kit Customized Service Offer
n/aELISA Kit for Intraflagellar Transport Protein 140 (IFT140)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Intraflagellar Transport Protein 140 (IFT140)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Intraflagellar Transport Protein 140 (IFT140)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Intraflagellar Transport Protein 140 (IFT140)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Intraflagellar Transport Protein 140 (IFT140)CLIA Kit Customized Service Offer
n/aELISA Kit for Intraflagellar Transport Protein 140 (IFT140)ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia."Genes Dev. 24:2180-2193(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Mainzer-Saldino syndrome is a ciliopathy caused by IFT140 mutations." Am. J. Hum. Genet. 90:864-870(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Combined NGS approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney Disease." Hum. Mutat. 34:714-724(2013) [PubMed] [Europe PMC] [Abstract]