p53-Regulated DNA Replication Inhibitor
Killin is a p53-regulated nuclear inhibitor of DNA synthesis, which lies in close proximity to pten on human chromosome 10 and encodes a 20-kDa nuclear protein. Killin is not only necessary but also sufficient for p53-induced apoptosis. Genetic and biochemical analysis demonstrates that Killin is a high-affinity DNA-binding protein, which potently inhibits eukaryotic DNA synthesis in vitro and appears to trigger S phase arrest before apoptosis in vivo. The DNA-binding domain essential for DNA synthesis inhibition was mapped to within 42 amino acid residues near the N terminus of Killin.
These results support Killin as a missing link between p53 activation and S phase checkpoint control designed to eliminate replicating precancerous cells, should they escape G(1) blockade mediated by p21.
Organism species: Homo sapiens (Human)
|CATALOG NO.||PRODUCT NAME||APPLICATIONS|
|Proteins||n/a||Recombinant Killin (KLLN)||Recombinant Protein Customized Service Offer|
|Antibodies||n/a||Monoclonal Antibody to Killin (KLLN)||Monoclonal Antibody Customized Service Offer|
|n/a||Polyclonal Antibody to Killin (KLLN)||Polyclonal Antibody Customized Service Offer|
|Assay Kits||n/a||CLIA Kit for Killin (KLLN)||CLIA Kit Customized Service Offer|
|n/a||ELISA Kit for Killin (KLLN)||ELISA Kit Customized Service Offer|
- "Killin is a p53-regulated nuclear inhibitor of DNA synthesis."Proc. Natl. Acad. Sci. U.S.A. 105:5396-5401(2008) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
- "Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome."JAMA 304:2724-2731(2010) [PubMed] [Europe PMC] [Abstract]