Killin (KLLN)


p53-Regulated DNA Replication Inhibitor

Killin (KLLN)
Killin is a p53-regulated nuclear inhibitor of DNA synthesis, which lies in close proximity to pten on human chromosome 10 and encodes a 20-kDa nuclear protein. Killin is not only necessary but also sufficient for p53-induced apoptosis. Genetic and biochemical analysis demonstrates that Killin is a high-affinity DNA-binding protein, which potently inhibits eukaryotic DNA synthesis in vitro and appears to trigger S phase arrest before apoptosis in vivo. The DNA-binding domain essential for DNA synthesis inhibition was mapped to within 42 amino acid residues near the N terminus of Killin.
These results support Killin as a missing link between p53 activation and S phase checkpoint control designed to eliminate replicating precancerous cells, should they escape G(1) blockade mediated by p21.

Organism species: Homo sapiens (Human)

Proteins n/a Recombinant Killin (KLLN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Killin (KLLN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Killin (KLLN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Killin (KLLN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Killin (KLLN) ELISA Kit Customized Service Offer
  1. "Killin is a p53-regulated nuclear inhibitor of DNA synthesis."Proc. Natl. Acad. Sci. U.S.A. 105:5396-5401(2008) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome."JAMA 304:2724-2731(2010) [PubMed] [Europe PMC] [Abstract]