Double Homeobox Protein 4 Like Protein 2 (DUX4L2)

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Double Homeobox Protein 4 Like Protein 2 (DUX4L2)
DUX4L2 Contains 2 homeobox DNA-binding domains. DUX4 is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals.
There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Double Homeobox Protein 4 Like Protein 2 (DUX4L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Double Homeobox Protein 4 Like Protein 2 (DUX4L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Double Homeobox Protein 4 Like Protein 2 (DUX4L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Double Homeobox Protein 4 Like Protein 2 (DUX4L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Double Homeobox Protein 4 Like Protein 2 (DUX4L2) ELISA Kit Customized Service Offer
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]