Enterovirus 71 (EV71)

nterovirus 71 (EV71) is a virus of the genus Enterovirus in the Picornaviridae family notable for its etiological role in epidemics of severe neurological diseases in children. his virus is a member of the enterovirus species A. The strains fall into six genogroups named A to F. Both the B and C genogroups have been subdivided into B0-B5 and C1-C5. The genogroup C appears to have evolved ~1970 while the A and B taxa evolved prior to this. Genogroup D was identified in India only and genogroups E and F in Africa only. Phylogenetic studies performed on partial sequences of viruses from India suggest that additional genogroups exist. The receptors for EV71 and CVA16 have been identified as P-selectin glycoprotein ligand-1 and scavenger receptor class B, member 2 (SCARB2); both are transmembrane proteins.