Irritable bowel syndrome (IBS) is a common medical condition characterized by chronic, recurrent, abdominal pain and discomfort, and altered bowel habits that occur in the absence of other organic gastrointestinal (GI) disease. IBS generates a significant health care burden and can severely impair quality of life.Altered gastrointestinal motility, visceral hypersensitivity, post infectious reactivity, brain-gut interactions, alteration in fecal micro flora, bacterial overgrowth, food sensitivity, carbohydrate malabsorption, and intestinal inflammation all have been implicated in the pathogenesis of IBS. A better understanding of the pathogenesis of IBS may help to develop new treatment......2023-07-31

On May 26, 2023,Wei He, Shanghai Skin Disease Hospital, Tongji University School of Medicine, China, and his team published a paper titled “Pulmonary endothelium-targeted nanoassembly of indomethacin and superoxide dismutase relieves lung inflammation” in Acta Pharmaceutica Sinica B. They developed the codelivery system based on rod-like pure crystals, which could well target the pulmonary endothelium and effectively alleviate lung inflammation.The kits[CLIA Kit for Tumor Necrosis Factor Alpha (TNFa), SCA133Mu; ELISA Kit for Interleukin 6 (IL6), SEA079Mu] of Cloud-Clone brand werechosed in this article, we are so proud for supporting the reaserchers.Lung inflammation is an essentia......2023-07-28

Through normal wear and tear, our tissues experience regular cell loss that is countered by replenishment mechanisms.Cardiomyocytes, the contractile cells of the heart, display an estimated turnover rate of 0.3 to 1% per year. Due to this low turnover rate, each of us will die with many or most of the cardiomyocytes we had at birth. In addition to longevity, cardiomyocytes possess brute strength and resilience. Their kryptonite is coronary artery occlusion and tissue ischemia, which can locally devastate the cardiomyocyte population and cause myocardial infarction (MI) with resultant scarring, along with nonischemic causes of muscle loss. Unfortunately, a scarred heart is much more lik......2023-07-24

On June 7, 2023,Hailing Qiao, Institute of Clinical Pharmacology, Zhengzhou University, China, and his team published a paper titled “Identification of Cytochrome P450 2E1 as a Novel Target in Glioma and Development of Its Inhibitor as an Anti-Tumor Agent” in Advanced Science. They discovered a previously unknown pro-tumorous mechanism in which the CYP2E1-PPARγ-STAT- 1/NF-κB/STAT-3/STAT-6 axis induced glioblastoma (GBM) cell proliferation and inhibited apoptosis to fuel tumorigenesis and tumor growth.The protein [Recombinant Cytochrome P450 2E1 (CYP2E1), RPA988Ra01] of Cloud-Clone brand waschosed in this article, we are so proud for supporting the reaserchers.Glioblastoma (GBM) i......2023-07-21

Cystic fibrosis (CF) is a multisystem autosomal recessive disease that is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR protein is an ion channel that functions to regulate the transepithelial movement of anions predominantly in mucus-secreting tissues, thereby acting to orchestrate the balancing of salt and fluid levels in mucus secretions. Disease-causing mutations in this gene affect multiple organs in CF including the gut, pancreas, and the liver, but it is the impact of dysregulated CFTR function in the airways that proves particularly harmful to individuals with CF. Dehydration of the airway surface liquid and thickening of m......2023-07-18

On June 20, 2023, Seon-Yong Jeong, Department of Medical Genetics, Ajou University School of Medicine, Korea, and his team published a paper titled “UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis” in Nature Communications. Their research suggested that UBAP2 has a critical role in bone homeostasis through the regulation of bone remodeling.The kits [ELISA Kit for Ubiquitin Associated Protein 2 (UBAP2), SEE593Hu] of Cloud-Clone brand were chosed in this article, we are so proud for supporting the reaserchers.Osteoporosis is a condition characterized by decreased bone mineral density (BMD) and reduced bone strength, leading t......2023-07-13