Inflammatory arthritis, including spinal arthritis (SpA) and rheumatoid arthritis (RA), are a kind of chronic inflammatory diseases, which will gradually damage the joints of patients and have a negative impact on normal life.SpA is characterized by inflammation in distinct anatomical sites and abnormal new bone formation in the entheses of the spine and peripheral joints; RA is characterized by the production of autoantibodies against extracellular matrix proteins and other targets, synovial inflammation and hyperplasia, and progressive cartilage and bone erosion.New progress in inflammatory arthritis researchThe use of anti-inflammatory drugs, including biologics, may relieve inflamm......2021-12-01

Cathepsin D is an important proteolytic enzyme, mainly distributed in intracellular vesicles, lysosomes, phagosomes and secondary endosomes. Its normal function is to participate in the catabolism of connective tissue. Current studies have shown that Cathepsin D is highly expressed in endometrial cancer, ovarian cancer, gastric cancer, breast cancer and other tumors, and plays an important role in the mechanism of malignant tumor cell infiltration and metastasis. Therefore, Cathepsin D detection is of great significance for the diagnosis and treatment evaluation of malignant tumor diseases.2021-11-29

On October 19, 2021, Hongtao Qin, School of Biology, Hunan University, and his team , published a paper titled "A pair of dopamine neurons mediate chronic stress signals to induce learning deficit in Drosophila melanogaster" on PNAS, which suggested that chronic stress causes dramatic learning and memory deficits in drosophila melanogaster.The ELISA Kits (ELISA Kit for Dopamine (DA), CEA851Ge) of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Chronic stress could induce severe cognitive impairments. Despite extensive investigations in mammalian models, the underlying mechanisms remain obscure. Here, we show that chronic stress cou......2021-11-23

Breast cancer (BC) is the most common malignancy in women. Due to advances in early diagnosis and comprehensive treatment strategies, the prognosis of breast cancer patients has improved. The disease has been divided into different subtypes, largely on the basis of the presence or absence of three key proteins: estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/ERBB2). Among them, triple negative breast cancer (TNBC) with negative expression of ER, PR and HER2/ERBB2 is the most difficult type of breast cancer treatment at present.New treatment strategies for TNBCTNBC has been characterized by several aggressive clinical features inclu......2021-11-18

Due to the small molecular weight, poor immunogenicity, and many homologs of chemical small molecules, the development of immunoassay kits is often difficult, and high-quality small molecule immunoassay kits are even more difficult to obtain.Cloud-Clone CORP. WUHAN, has developed small molecule detection kits as its own characteristic project from the beginning of its establishment, and has developed and accumulated small molecule modification and coupling technology, small molecule immunity technology and homolog screening technology for nearly 10 years. It has formed its own technical system in small molecule modification, immunity and antibody preparation. Up to now, the small molec......2021-11-17

Cytokines are a class of low molecular weight soluble proteins gradually formed in the evolution of higher animals in response to the changes in the internal and external environment of organisms. They have many functions such as regulating innate immunity, adaptive immunity, hematopoiesis, cell growth and repair of damaged tissues. At present, more than 100 types of cytokines have been discovered, which can be divided into interleukin (IL), interferon (IFN), colony stimulating factor (CSF), tumor necrosis factor (TNF), erythropoietin (EPO) and other types according to their functions. With the further research, the total number of cytokines has changed year by year. After more than 10......2021-11-17