On May 19, 2023,Zhen Gu, and Jicheng Yu, Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, China, and his team published a paper titled “T cell-mimicking platelet-drug conjugates” in Matter. They demonstrated that the platelet-drug conjugates (PDCs) significantly suppressed lung metastasis in two tumor models, B16F10 melanomas and 4T1 breast carcinomas.The antibodies[Polyclonal Antibody to Thrombospondin 1 (THBS1), PAA611Mu01; Polyclonal Antibody to Perforin 1 (PRF1), PAB317Mu01; Polyclonal Antibody to Granzyme B (GZMB), PAA600Mu01] of Cloud-Clone brand were chosed in this article, we are so proud for sup......2023-06-21

Over the past few years, the incidence of the pancreatic cancer has increased, and is expected to continue to represent a leading cause of cancer-related mortality. Most patients have no obvious symptoms during disease development and progression to advanced metastasis pancreatic, whereby tumor cells are highly invasive. Early diagnosis is difficult, and it has become one of the most deadly malignant tumors. Most patients eventually relapse, even after a potential radical treatment, the patient’s 5-year survival rate is only 2%-9%.Recently, many papers reported the new progress of pancreatic cancer research, which may help the treatment of pancreatic cancer and improve the prognosis ......2023-06-19

On April 29, 2023, Pei-Gang Wang, Jing An, Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, China, Yong-Tang Zheng, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, China, and his team published a paper titled “Single-cell RNA sequencing reveals the fragility of male spermatogenic cells to Zika virus-induced complement activation” in Nature Communications. They revealed the fragility of spermatogenic cells, especially spermatogonia, to ZIKV infection.The kits[ELISA Kit for Complement 1q (C1q), SEA747Mu；ELISA Kit for Mannose Associated Ser......2023-06-16

The retina is a visual nerve endings extending outward from the brain. Its function is to receive external light stimuli, convert them into physiological stimuli through photochemical reactions, and transmit them to the central nervous system to generate vision. Any retinal disease can cause visual impairment, and the degree of damage varies depending on the severity and location of the lesion. Common retinal diseases include diabetic retinopathy (DR), retinal vascular occlusion, retinitis pigmentosa, age-related macular degeneration (AMD), glaucoma and retinopathy of prematurity. Recently, multiple studies have reported on retinal diseases, which may provide assistance for the prevent......2023-06-12

As a lytic and inflammatory type of regulated cell death, pyroptosis is characterized by cell swelling, lysis, and the release of many proinflammatory factors, including IL1β, IL-18, ATP, and HMGB1. Dying cells activate pyroptosis through the following two main approaches: (i) GSDMD (gasdermin D)-dependent activation regulated by caspase 1/4/5/11 and (ii) GSDME-dependent activation regulated by caspase 3. Activated caspases cleave the hinge region between the N- and C-terminal domains of GSDMD or GSDME, releasing the segment with lethal activity and leading to pyroptosis. Few studies investigated the roles of other GSDM family members in pyroptosis, but GSDMA, GSDMB, and GSDMC also ha......2023-06-05

On March 22, 2023,Guanwei Fan, State Key Laboratory of Modern Chinese Medicine, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae for the Ministry of Education, Tianjin University of Traditional Chinese Medicine, China, and his team published a paper titled “M2 Macrophage-Derived sEV Regulate Pro-Inflammatory CCR2+Macrophage Subpopulations to Favor Post-AMI Cardiac Repair” in Advanced Science. The results of their study provide evidence for the role of M2EVin polarizing cardiac-resident CCR2+macrophages to an M2- like phenotype, resulting in reduced recruitment of circulating CCR2+monocytes, and an improved myocardial tissue microenvironment for cardiac tissue ......2023-06-01