Parkinson’s disease (PD) is the second most common neurodegenerative disease, affecting millions of individuals. These motor signs are usually preceded by non-motor manifestations such as olfactory dysfunction, rapid eye movement sleep behaviour disorder, depression, and constipation.Additionally, over the course of the disease, cognitive impairment also develops with progression to dementia in up to 80% of the patients. New progress in Parkinson's disease researchThe cardinal motor symptoms of PD are caused by the loss of dopaminergic neurons in the substantia nigra that modulate basal ganglia circuits regulating habitual and goal-directed movement. The pathogenesis of PD is und......2022-03-07

On 27 January 2022, Johannes Keller, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Germany, and his team published a paper tittled “Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment” in Bone Research, which revealed a potential role of osteoblast-derived procalcitonin (ProCT) in the bone microenvironment.The Antibody[Polyclonal Antibody to Procalcitonin (PCT), PAA689Mu01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Intermittent injections of parathyroid hormone (iPTH) are applied clinically to......2022-03-03

Myocardial hypertrophyis a slowly developing compensatory mechanism of cardiac function, which mainly occurs in the case of long-term stress overload. It is manifested as an increase in the total amount of cardiac muscle and a strengthening of its contractility, so that the heart can maintain normal blood circulation.However, this compensatory function also has its disadvantages, mainly because hypertrophy myocardial oxygen demand increases, and coronary artery blood supply often can not be satisfied, resulting in myocardial ischemia, which will eventually lead to the decrease of myocardial contractility.Targeting myocardial hypertrophy in the treatment of heart failureHeart failure (H......2022-02-25

On 6 January 2022, William Ka Kei Wu, Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, and his team published a paper tittled “Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification”in Autophagy, which showed that Vitamin D3 and carbamazepine protect against Clostridioides difficileinfection (CDI) by restoring melanocyte inducing transcription factor (MITF) expression and lysosomal function in mice.The kits [ELISA Kit for Interleukin 8 (IL8), SEA080Hu; ELISA Kit for Chemokine (C-X-C Motif) Ligand 2 (CXCL2), SEB603Hu/SEB603Mu] of Cloud-Clone brand was chosed in this arti......2022-02-24

The kidneys, as a major filter organ for the blood and the key organ responsible for maintaining total body water balance and circulatory pressure, receive a rich blood supply by which they monitor and modify the functional status of multiple organ systems. Overall, 10% of the world's adults had some form of kidney disease. Kidney diseases are related to a massive financial burden.New discovery on the pathogenesis of kidney diseasesChronic kidney disease (CKD) is a clinical syndrome secondary to the definitive change in function and/or structure of the kidney and is characterized by its irreversibility and slow and progressive evolution. CKD affects a variety of metabolic pathways,......2022-02-18

On 14 January 2022, Christian Grimm, Ludwig-Maximilians-University, Munich, Germany, and his team published a paper tittled “Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice” in NATURE COMMUNICATIONS , which suggested that TRPML3 represents a key regulator of MMP-12 clearance by alveolar macrophages and may serve as therapeutic target for emphysema and chronic obstructive pulmonary disease.The kits [ELISA Kit for Matrix Metalloproteinase 12 (MMP12), SEA402Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Lung emphysema and chronic bronchitis are the two most common causes of chronic obstructive......2022-02-18