Brain Derived Neurotrophic Factor (BDNF)

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Neurotrophin; Abrineurin

Brain Derived Neurotrophic Factor (BDNF)

BDNF is a 13 kDa, 119 amino acid (aa) residue non-glycosylated polypeptide whose primary structure is conserved among all mammalian species examined. Initially synthesized as a 247 aa residue prepropeptide, the BDNF molecule is divided into an 18 aa residue signal sequence, a 110 aa residue prosequence, and a 119 aa residue mature segment.

Similar to other neurotrophic factors, there is a possibility that the N-terminus is alternatively spliced, giving rise to a longer pre-prosegment (but identical mature segment) with different functional properties. As a mature molecule, BDNF is 52% identical to NGF at the amino acid level, exists as a noncovalently-linked homodimer in solution, and contains six cysteine residues that are believed to form three intrachain disulfide linkages.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA011Hu01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP.
EPA011Hu61Eukaryotic Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling.
APA011Hu61Active Brain Derived Neurotrophic Factor (BDNF)Cell culture; Activity Assays; In vivo assays.
RPA011Mi01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAA011Hu01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
MAA011Hu22Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
LAA011Hu71Biotin-Linked Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; IF; ELISA.
LAA011Hu81FITC-Linked Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)IHC;ICC;IF;WB
PAA011Hu06Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
PAA011Mi01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA011Mi26Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA011Mi76Biotin-Linked Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay KitsSCA011HuCLIA Kit for Brain Derived Neurotrophic Factor (BDNF)Chemiluminescent immunoassay for Antigen Detection
SEA011MiELISA Kit for Brain Derived Neurotrophic Factor (BDNF)Enzyme-linked immunosorbent assay for Antigen Detection
SEA011HuELISA Kit for Brain Derived Neurotrophic Factor (BDNF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA011Mu01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
RPA011Mu02Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP.
RPA011Mi01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAA011Mu01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
PAA011Mu02Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
PAA011Mi01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA011Mi26Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA011Mi76Biotin-Linked Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay KitsSEA011MiELISA Kit for Brain Derived Neurotrophic Factor (BDNF)Enzyme-linked immunosorbent assay for Antigen Detection
SEA011MuELISA Kit for Brain Derived Neurotrophic Factor (BDNF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA011Ra01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
RPA011Mi01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAA011Ra01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA011Ra21Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
PAA011Mi01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA011Mi26Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA011Mi76Biotin-Linked Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay KitsSEA011MiELISA Kit for Brain Derived Neurotrophic Factor (BDNF)Enzyme-linked immunosorbent assay for Antigen Detection
SEA011RaELISA Kit for Brain Derived Neurotrophic Factor (BDNF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Cavia (Guinea pig )

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA011Gu01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA011Gu01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
MAA011Gu21Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA011GuELISA Kit for Brain Derived Neurotrophic Factor (BDNF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA011Rb01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP.
RPA011Rb02Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP.
RPA011Mi01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAA011Rb52Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
PAA011Rb51Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
PAA011Mi01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA011Mi26Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA011Mi76Biotin-Linked Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay KitsSEA011MiELISA Kit for Brain Derived Neurotrophic Factor (BDNF)Enzyme-linked immunosorbent assay for Antigen Detection
SEA011RbELISA Kit for Brain Derived Neurotrophic Factor (BDNF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA011Ca01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA011Ca01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
MAA011Ca21Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Brain Derived Neurotrophic Factor (BDNF)CLIA Kit Customized Service Offer
n/aELISA Kit for Brain Derived Neurotrophic Factor (BDNF)ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA011Po01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
RPA011Mi01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAA011Po01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
MAA011Po21Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA011Po26Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA011Po76Biotin-Linked Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; IF; ELISA.
PAA011Mi01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA011Mi26Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA011Mi76Biotin-Linked Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay Kitsn/aCLIA Kit for Brain Derived Neurotrophic Factor (BDNF)CLIA Kit Customized Service Offer
n/aELISA Kit for Brain Derived Neurotrophic Factor (BDNF)ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA011Bo01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA011Bo01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
MAA011Bo21Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Brain Derived Neurotrophic Factor (BDNF)CLIA Kit Customized Service Offer
n/aELISA Kit for Brain Derived Neurotrophic Factor (BDNF)ELISA Kit Customized Service Offer

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA011Mi01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAA011Mi01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA011Mi26Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA011Mi76Biotin-Linked Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay KitsSEA011MiELISA Kit for Brain Derived Neurotrophic Factor (BDNF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Brain Derived Neurotrophic Factor (BDNF)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Brain Derived Neurotrophic Factor (BDNF)CLIA Kit Customized Service Offer
n/aELISA Kit for Brain Derived Neurotrophic Factor (BDNF)ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA011Eq01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP.
RPA011Mi01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAA011Eq01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
PAA011Mi01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAA011Mi26Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAA011Mi76Biotin-Linked Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay KitsSEA011MiELISA Kit for Brain Derived Neurotrophic Factor (BDNF)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Chicken (Gallus)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA011Ga01Recombinant Brain Derived Neurotrophic Factor (BDNF)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA011Ga01Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)WB, ICC, IHC-P, IHC-F, ELISA
LAA011Ga71Biotin-Linked Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)IHC;WB;ELISA
Assay Kitsn/aCLIA Kit for Brain Derived Neurotrophic Factor (BDNF)CLIA Kit Customized Service Offer
n/aELISA Kit for Brain Derived Neurotrophic Factor (BDNF)ELISA Kit Customized Service Offer
  1. "Molecular cloning of a human gene that is a member of the nerve growth factor family."Proc. Natl. Acad. Sci. U.S.A. 87:8060-8064(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the 5'-flanking region of the human brain-derived neurotrophic factor gene."Biochem. Biophys. Res. Commun. 182:325-332(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease."Am. J. Med. Genet. B Neuropsychiatr. Genet. 134:93-103(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters."Genomics 90:397-406(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Purification and identification of brain-derived neurotrophic factor from human serum."Protein Expr. Purif. 6:465-471(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular phylogenetics and the origins of placental mammals."Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor."J. Biol. Chem. 276:12660-12666(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations." Hum. Mol. Genet. 13:1205-1212(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Brain-derived neurotrophic factor and obesity in the WAGR syndrome."N. Engl. J. Med. 359:918-927(2008) [PubMed] [Europe PMC] [Abstract]
  15. ErratumN. Engl. J. Med. 359:1414-1414(2008)
  16. "Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer."Biochemistry 34:4139-4146(1995) [PubMed] [Europe PMC] [Abstract]
  17. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  18. ErratumNat. Genet. 23:373-373(1999)
  19. "Idiopathic congenital central hypoventilation syndrome: evaluation of brain-derived neurotrophic factor genomic DNA sequence variation."Am. J. Med. Genet. 107:306-310(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder."Am. J. Hum. Genet. 73:370-376(2003) [PubMed] [Europe PMC] [Abstract]
  21. "The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function."Cell 112:257-269(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Molecular analysis of congenital central hypoventilation syndrome."Hum. Genet. 114:22-26(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type."Mol. Psychiatry 8:745-751(2003) [PubMed] [Europe PMC] [Abstract]