Interleukin 13 (IL13)

[Edit]

ALRH; BHR1; P600; IL-13; NC30

Interleukin 13 (IL13)

Interleukin 13 (IL-13) is produced primarily by activated T lymphocytes. It shows approximately 30% amino acid (aa) sequence identity with IL-4 and shares many biological properties with IL-4. IL-13 has multiple effects on the differentiation and functions of monocytes/macrophages. It can suppress the cytotoxic functions of monocytes/macrophages and the production of proinflammatory cytokines by monocytes/macrophages. The biological effects of IL-13 are mediated by specific high-affinity cell surface receptor complexes. The functional IL-13 receptor complex has been shown to consist of the low-affinity IL-13 receptor α chain and the IL-4 receptor α subunit (IL-4 Rα). This IL-13 receptor complex may also serve as an alternate high-affinity IL-4 receptor complex in IL-4 responsive cells that lack the γ chain.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA060Hu01Recombinant Interleukin 13 (IL13)SDS-PAGE; WB; ELISA; IP.
APA060Hu01Active Interleukin 13 (IL13)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA060Hu01Polyclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
MAA060Hu22Monoclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA060HuELISA Kit for Interleukin 13 (IL13)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA060Mu01Recombinant Interleukin 13 (IL13)SDS-PAGE; WB; ELISA; IP; CoIP; ReporterAssays; Purification; Amine Reactive Labeling.
RPA060Mu02Recombinant Interleukin 13 (IL13)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA060Mu01Polyclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
PAA060Mu02Polyclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA060MuELISA Kit for Interleukin 13 (IL13)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA060Ra01Recombinant Interleukin 13 (IL13)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA060Ra01Polyclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
MAA060Ra21Monoclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA060RaELISA Kit for Interleukin 13 (IL13)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA060Si01Recombinant Interleukin 13 (IL13)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA060Si01Polyclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Interleukin 13 (IL13)CLIA Kit Customized Service Offer
n/aELISA Kit for Interleukin 13 (IL13)ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA060Ca01Recombinant Interleukin 13 (IL13)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA060Ca01Polyclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
MAA060Ca21Monoclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA060CaELISA Kit for Interleukin 13 (IL13)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA060Po01Recombinant Interleukin 13 (IL13)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA060Po01Polyclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
MAA060Po21Monoclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA060PoELISA Kit for Interleukin 13 (IL13)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA060Bo01Recombinant Interleukin 13 (IL13)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAA060Bo01Polyclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
MAA060Bo21Monoclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA060BoELISA Kit for Interleukin 13 (IL13)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA060Cp01Recombinant Interleukin 13 (IL13)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA060Cp01Polyclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Interleukin 13 (IL13)CLIA Kit Customized Service Offer
n/aELISA Kit for Interleukin 13 (IL13)ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA060Eq01Recombinant Interleukin 13 (IL13)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA060Eq01Polyclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
MAA060Eq21Monoclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA060EqELISA Kit for Interleukin 13 (IL13)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Chicken (Gallus)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA060Ga01Recombinant Interleukin 13 (IL13)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA060Ga01Polyclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
MAA060Ga21Monoclonal Antibody to Interleukin 13 (IL13)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA060GaELISA Kit for Interleukin 13 (IL13)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses."Nature 362:248-250(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function."Proc. Natl. Acad. Sci. U.S.A. 90:3735-3739(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization."Gene 155:277-281(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31."Blood 87:3316-3326(1996) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes."Nucleic Acids Res. 20:5173-5179(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Solution structure of human IL-13 and implication for receptor binding."J. Mol. Biol. 310:219-230(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2."Structure 18:332-342(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Genetic variants of IL-13 signalling and human asthma and atopy." Hum. Mol. Genet. 9:549-559(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population."Am. J. Respir. Cell Mol. Biol. 25:377-384(2001) [PubMed] [Europe PMC] [Abstract]
  12. "A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis."Hum. Genet. 113:387-390(2003) [PubMed] [Europe PMC] [Abstract]