Hexosaminidase A Alpha (HEXa)

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TSD; Hex-A; Tay Sachs Disease; GM2 Gangliosidosis; Beta-Hexosaminidase Subunit Alpha; Beta-N-Acetylhexosaminidase Subunit Alpha; N-Acetyl-Beta-Glucosaminidase Alpha

Hexosaminidase A Alpha (HEXa)

Hexosaminidase A (alpha polypeptide), is an enzyme that is encoded by the HEXA gene.β-hexosaminidase occurs as two major isozymes: hexosaminidase A and hexosaminidase B. Hexosaminidase A and the cofactor GM2 activator protein catalyze the degradation of the GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines. Hexosaminidase A is a heterodimer composed of an alpha and beta subunit. The alpha subunit is encoded by the HEXA gene while the beta subunit is encoded by the HEXB gene. Gene mutations in the gene encoding the beta subunit (HEXB) often result in Sandhoff disease; whereas, mutations in the gene encoding the alpha subunit (HEXA, this gene) decrease the hydrolysis of GM2 gangliosides, which is the main cause of Tay-Sachs disease.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA195Hu01Recombinant Hexosaminidase A Alpha (HEXa)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA195Hu01Polyclonal Antibody to Hexosaminidase A Alpha (HEXa)WB; IHC; ICC; IP.
MAA195Hu22Monoclonal Antibody to Hexosaminidase A Alpha (HEXa)WB; IHC; ICC; IP.
Assay KitsSEA195HuELISA Kit for Hexosaminidase A Alpha (HEXa)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA195Mu01Recombinant Hexosaminidase A Alpha (HEXa)Positive Control; Immunogen; SDS-PAGE; WB.
RPA195Mu02Recombinant Hexosaminidase A Alpha (HEXa)Positive Control; Immunogen; SDS-PAGE; WB.
APA195Mu01Active Hexosaminidase A Alpha (HEXa)Cell culture; Activity Assays.
AntibodiesPAA195Mu01Polyclonal Antibody to Hexosaminidase A Alpha (HEXa)WB; IHC; ICC; IP.
PAA195Mu02Polyclonal Antibody to Hexosaminidase A Alpha (HEXa)WB; IHC; ICC; IP.
Assay KitsSEA195MuELISA Kit for Hexosaminidase A Alpha (HEXa)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Hexosaminidase A Alpha (HEXa)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Hexosaminidase A Alpha (HEXa)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Hexosaminidase A Alpha (HEXa)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Hexosaminidase A Alpha (HEXa)CLIA Kit Customized Service Offer
n/aELISA Kit for Hexosaminidase A Alpha (HEXa)ELISA Kit Customized Service Offer
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