Laminin Alpha 1 (LAMA1)

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LAM-A1; LAMA; Laminin A; LaMa1; S-laminin subunit alpha

Laminin Alpha 1 (LAMA1)

Laminin is a basement membrane protein composed of 3 nonidentical chains, A (400 kD), B1 (230 kD), and B2 (220 kD), which are arranged in a cross-shaped structure. Mattei et al. (1989) used in situ hybridization to localize the human laminin A locus to chromosome 18p11.31.By study of mouse-Chinese hamster somatic cell hybrids, Kaye et al. assigned the gene for laminin A to mouse chromosome 17 and confirmed the assignment of the gene for laminin B2 to mouse chromosome 1. Haaparanta et al. reported the nucleotide sequence of LAMA cDNA. They found an open reading frame encoding 3,075 amino acids. Nissinen et al. reported that the complete human laminin A chain contains a 17-amino acid signal peptide and a 3,058-residue A chain proper. The chain has a distinct domain structure with numerous internal cysteine-rich repeats.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA574Hu01 Recombinant Laminin Alpha 1 (LAMA1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA574Hu02 Recombinant Laminin Alpha 1 (LAMA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA574Hu01 Polyclonal Antibody to Laminin Alpha 1 (LAMA1) WB; IHC; ICC; IP.
PAA574Hu02 Polyclonal Antibody to Laminin Alpha 1 (LAMA1) WB; IHC; ICC; IP.
LAA574Hu71 Biotin-Linked Polyclonal Antibody to Laminin Alpha 1 (LAMA1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Laminin Alpha 1 (LAMA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Laminin Alpha 1 (LAMA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA574Mu01 Recombinant Laminin Alpha 1 (LAMA1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA574Mu02 Recombinant Laminin Alpha 1 (LAMA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA574Mu01 Polyclonal Antibody to Laminin Alpha 1 (LAMA1) WB; IHC; ICC; IP.
LAA574Mu71 Biotin-Linked Polyclonal Antibody to Laminin Alpha 1 (LAMA1) WB; IHC; ICC.
PAA574Mu02 Polyclonal Antibody to Laminin Alpha 1 (LAMA1) WB; IHC; ICC; IP.
Assay Kits SEA574Mu ELISA Kit for Laminin Alpha 1 (LAMA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA574Ra01 Recombinant Laminin Alpha 1 (LAMA1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA574Ra02 Recombinant Laminin Alpha 1 (LAMA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA574Ra01 Polyclonal Antibody to Laminin Alpha 1 (LAMA1) WB; IHC; ICC; IP.
PAA574Ra02 Polyclonal Antibody to Laminin Alpha 1 (LAMA1) WB; IHC; ICC; IP.
Assay Kits SEA574Ra ELISA Kit for Laminin Alpha 1 (LAMA1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of the cDNA encoding human laminin A chain."Matrix 11:151-160(1991) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Primary structure of the human laminin A chain. Limited expression in human tissues."Biochem. J. 276:369-379(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells."Lab. Invest. 60:772-782(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in LAMA1 cause cerebellar dysplasia and cysts with and without retinal dystrophy."Am. J. Hum. Genet. 95:227-234(2014) [PubMed] [Europe PMC] [Abstract]
  7. "A secreted tyrosine kinase acts in the extracellular environment."Cell 158:1033-1044(2014) [PubMed] [Europe PMC] [Abstract]