≡

Estrogen Receptor Alpha (ERa)

[Edit]

ER-A1; ER; ESR; ESR1; ESRA; NR3A1; NR3-A1; Estrogen Receptor 1; Nuclear Receptor Subfamily 3,Group A,Member 1

Estrogen Receptor Alpha (ERa)
CCC B050
HGNC 3467
MGI 1352467
PubMed 14973389
RGD 2581
UniProt P03372
Wiki ERA
Estrogen receptor structure-function is a vast topic and the subject of very active current research. Nuclear receptors are a large family of structurally related ligand-inducible transcription factors, including steroid receptors (SRs), thyroid/retinoids receptors (TR, RARs and RXRs), vitamin D receptors (VDR), LXR, PPARs, estrogen receptors (ERα and ERβ), and orphan receptors for which no ligand has been yet identified. While having in common a modular structure, they are activated by distinct lipophilic small molecules such as glucocorticoids, progesterone, estrogens, retinoids, and fatty acid derivatives.All nuclear receptors have a hydrophobic pocket into which its specific ligand binds, with helix 12 (H12) being the key response element of NRs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB050Hu01 Recombinant Estrogen Receptor Alpha (ERa) Positive Control; Immunogen; SDS-PAGE; WB.
RPB050Hu02 Recombinant Estrogen Receptor Alpha (ERa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB050Hu01 Polyclonal Antibody to Estrogen Receptor Alpha (ERa) WB; IHC; ICC; IP.
MAB050Hu22 Monoclonal Antibody to Estrogen Receptor Alpha (ERa) WB; IHC; ICC; IP.
Assay Kits SEB050Hu ELISA Kit for Estrogen Receptor Alpha (ERa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB050Mu01 Recombinant Estrogen Receptor Alpha (ERa) Positive Control; Immunogen; SDS-PAGE; WB.
RPB050Mu02 Recombinant Estrogen Receptor Alpha (ERa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB050Mu01 Polyclonal Antibody to Estrogen Receptor Alpha (ERa) WB; IHC; ICC; IP.
PAB050Mu02 Polyclonal Antibody to Estrogen Receptor Alpha (ERa) WB; IHC; ICC; IP.
Assay Kits SEB050Mu ELISA Kit for Estrogen Receptor Alpha (ERa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB050Ra01 Recombinant Estrogen Receptor Alpha (ERa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB050Ra01 Polyclonal Antibody to Estrogen Receptor Alpha (ERa) WB; IHC; ICC; IP.
MAB050Ra21 Monoclonal Antibody to Estrogen Receptor Alpha (ERa) WB; IHC; ICC; IP.
Assay Kits SEB050Ra ELISA Kit for Estrogen Receptor Alpha (ERa) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A."Nature 320:134-139(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence and expression of human estrogen receptor complementary DNA."Science 231:1150-1154(1986) [PubMed] [Europe PMC] [Abstract]
  3. "A novel 80 kDa human estrogen receptor containing a duplication of exons 6 and 7."Nucleic Acids Res. 24:962-969(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66."Biochem. Biophys. Res. Commun. 336:1023-1027(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor."Mol. Endocrinol. 9:1041-1052(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Single nucleotide polymorphisms (SNPs) in the estrogen receptor gene and breast cancer susceptibility."J. Steroid Biochem. Mol. Biol. 71:21-27(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Estrogen receptor variant messenger RNA lacking exon 4 in estrogen-responsive human breast cancer cell lines."Cancer Res. 53:741-743(1993) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro."Mol. Endocrinol. 9:24-33(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of a temperature-sensitive mutation in the hormone binding domain of the human estrogen receptor. Studies in cell extracts and intact cells and their implications for hormone-dependent transcriptional activation."J. Biol. Chem. 267:9868-9873(1992) [PubMed] [Europe PMC] [Abstract]
  13. "Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor."Mol. Endocrinol. 8:1208-1214(1994) [PubMed] [Europe PMC] [Abstract]
  14. "Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta."Mol. Cell. Biol. 15:4971-4979(1995) [PubMed] [Europe PMC] [Abstract]
  15. "Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha."Mol. Cell. Biol. 19:5363-5372(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1."EMBO J. 19:4688-4700(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Function of N-terminal transactivation domain of the estrogen receptor requires a potential alpha-helical structure and is negatively regulated by the A domain."Mol. Endocrinol. 14:1849-1871(2000) [PubMed] [Europe PMC] [Abstract]
  18. "Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells."Mol. Endocrinol. 17:589-599(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells."Proc. Natl. Acad. Sci. U.S.A. 100:4807-4812(2003) [PubMed] [Europe PMC] [Abstract]
  20. "A subpopulation of estrogen receptors are modified by O-linked N-acetylglucosamine."J. Biol. Chem. 272:2421-2428(1997) [PubMed] [Europe PMC] [Abstract]
  21. "Functional synergy between the transcription factor Sp1 and the estrogen receptor."Mol. Endocrinol. 11:1569-1580(1997) [PubMed] [Europe PMC] [Abstract]
  22. "Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action."Oncogene 16:2513-2526(1998) [PubMed] [Europe PMC] [Abstract]
  23. "Potentiation of human estrogen receptor alpha transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex."J. Biol. Chem. 274:22296-22302(1999) [PubMed] [Europe PMC] [Abstract]
  24. "A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."J. Biol. Chem. 274:34283-34293(1999) [PubMed] [Europe PMC] [Abstract]
  25. "An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens."Proc. Natl. Acad. Sci. U.S.A. 96:6947-6952(1999) [PubMed] [Europe PMC] [Abstract]
  26. "Synergy between estrogen receptor alpha activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2."EMBO Rep. 1:151-157(2000) [PubMed] [Europe PMC] [Abstract]
  27. "Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements."J. Biol. Chem. 275:5379-5387(2000) [PubMed] [Europe PMC] [Abstract]
  28. "Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins."J. Biol. Chem. 275:22769-22779(2000) [PubMed] [Europe PMC] [Abstract]
  29. "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein."Genes Dev. 15:2598-2612(2001) [PubMed] [Europe PMC] [Abstract]
  30. "Characterization of the physical interaction between estrogen receptor alpha and JUN proteins."J. Biol. Chem. 276:36361-36369(2001) [PubMed] [Europe PMC] [Abstract]
  31. "Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription."J. Biol. Chem. 276:28402-28412(2001) [PubMed] [Europe PMC] [Abstract]
  32. "CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant."Mol. Cell. Biol. 21:343-353(2001) [PubMed] [Europe PMC] [Abstract]
  33. "Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains."Mol. Endocrinol. 15:1953-1970(2001) [PubMed] [Europe PMC] [Abstract]
  34. "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."J. Biol. Chem. 277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]
  35. "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor."J. Biol. Chem. 277:33571-33579(2002) [PubMed] [Europe PMC] [Abstract]
  36. "ERAP140, a conserved tissue-specific nuclear receptor coactivator."Mol. Cell. Biol. 22:3358-3372(2002) [PubMed] [Europe PMC] [Abstract]
  37. "A negative coregulator for the human ER."Mol. Endocrinol. 16:459-468(2002) [PubMed] [Europe PMC] [Abstract]
  38. "Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade."Proc. Natl. Acad. Sci. U.S.A. 99:14783-14788(2002) [PubMed] [Europe PMC] [Abstract]
  39. "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation."Mol. Cell. Biol. 23:6210-6220(2003) [PubMed] [Europe PMC] [Abstract]
  40. "ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor."Biochem. Biophys. Res. Commun. 317:54-59(2004) [PubMed] [Europe PMC] [Abstract]
  41. "The relative contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor alpha transcriptional activity depends upon the differentiation stage of the cell."J. Biol. Chem. 279:26184-26191(2004) [PubMed] [Europe PMC] [Abstract]
  42. "An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling."J. Biol. Chem. 279:38721-38729(2004) [PubMed] [Europe PMC] [Abstract]
  43. "Protein phosphatase 5 is a negative regulator of estrogen receptor-mediated transcription."Mol. Endocrinol. 18:1131-1143(2004) [PubMed] [Europe PMC] [Abstract]
  44. "Estrogen receptor inhibits interleukin-6 gene expression by disruption of nuclear factor kappaB transactivation."Cytokine 31:251-257(2005) [PubMed] [Europe PMC] [Abstract]
  45. "Functional regulation of oestrogen receptor pathway by the dynein light chain 1."EMBO Rep. 6:538-544(2005) [PubMed] [Europe PMC] [Abstract]
  46. ErratumEMBO Rep. 6:1101-1101(2005)
  47. "The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1."Oncogene 24:5576-5588(2005) [PubMed] [Europe PMC] [Abstract]
  48. "Identification of the MLL2 complex as a coactivator for estrogen receptor alpha."J. Biol. Chem. 281:15714-15720(2006) [PubMed] [Europe PMC] [Abstract]
  49. "Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells."J. Biol. Chem. 281:19092-19099(2006) [PubMed] [Europe PMC] [Abstract]
  50. "MUC1 oncoprotein stabilizes and activates estrogen receptor alpha."Mol. Cell 21:295-305(2006) [PubMed] [Europe PMC] [Abstract]
  51. "ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases."Nucleic Acids Res. 34:6126-6136(2006) [PubMed] [Europe PMC] [Abstract]
  52. "MTA1, a transcriptional activator of breast cancer amplified sequence 3."Proc. Natl. Acad. Sci. U.S.A. 103:6670-6675(2006) [PubMed] [Europe PMC] [Abstract]
  53. ErratumProc. Natl. Acad. Sci. U.S.A. 110:4147-4148(2013)
  54. "An inherent role of microtubule network in the action of nuclear receptor."Proc. Natl. Acad. Sci. U.S.A. 103:15981-15986(2006) [PubMed] [Europe PMC] [Abstract]
  55. "The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain."Biochem. Biophys. Res. Commun. 361:127-132(2007) [PubMed] [Europe PMC] [Abstract]
  56. "CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome."EMBO J. 26:1831-1842(2007) [PubMed] [Europe PMC] [Abstract]
  57. "Estrogenically regulated LRP16 interacts with estrogen receptor alpha and enhances the receptor's transcriptional activity."Endocr. Relat. Cancer 14:741-753(2007) [PubMed] [Europe PMC] [Abstract]
  58. "MS-KIF18A, a kinesin, is associated with estrogen receptor."J. Cell. Biochem. 100:693-702(2007) [PubMed] [Europe PMC] [Abstract]
  59. "PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor."J. Steroid Biochem. Mol. Biol. 107:1-14(2007) [PubMed] [Europe PMC] [Abstract]
  60. "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)."Mol. Endocrinol. 21:1847-1860(2007) [PubMed] [Europe PMC] [Abstract]
  61. "Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha."Nucleic Acids Res. 35:1673-1686(2007) [PubMed] [Europe PMC] [Abstract]
  62. "ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification."Proc. Natl. Acad. Sci. U.S.A. 104:18067-18072(2007) [PubMed] [Europe PMC] [Abstract]
  63. "ERalpha and AP-1 interact in vivo with a specific sequence of the F promoter of the human ERalpha gene in osteoblasts."J. Cell. Physiol. 216:101-110(2008) [PubMed] [Europe PMC] [Abstract]
  64. "Regulation of estrogen rapid signaling through arginine methylation by PRMT1."Mol. Cell 31:212-221(2008) [PubMed] [Europe PMC] [Abstract]
  65. "CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor."Mol. Endocrinol. 22:263-272(2008) [PubMed] [Europe PMC] [Abstract]
  66. "MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene."Oncogene 27:1971-1980(2008) [PubMed] [Europe PMC] [Abstract]
  67. "ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells."Prostate 68:1273-1282(2008) [PubMed] [Europe PMC] [Abstract]
  68. "SH2D4A regulates cell proliferation via the ERalpha/PLC-gamma/PKC pathway."BMB Rep. 42:516-522(2009) [PubMed] [Europe PMC] [Abstract]
  69. "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer."Cancer Res. 69:128-136(2009) [PubMed] [Europe PMC] [Abstract]
  70. "Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia."Hum. Mol. Genet. 18:2802-2812(2009) [PubMed] [Europe PMC] [Abstract]
  71. "NF-kappaB and estrogen receptor alpha interactions: Differential function in estrogen receptor-negative and -positive hormone-independent breast cancer cells."J. Cell. Biochem. 107:448-459(2009) [PubMed] [Europe PMC] [Abstract]
  72. "OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity."J. Biol. Chem. 284:16135-16145(2009) [PubMed] [Europe PMC] [Abstract]
  73. "CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions."Nucleic Acids Res. 37:3110-3123(2009) [PubMed] [Europe PMC] [Abstract]
  74. "The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer."Oncogene 28:4053-4064(2009) [PubMed] [Europe PMC] [Abstract]
  75. "The regulation of MS-KIF18A expression and cross talk with estrogen receptor."PLoS ONE 4:E6407-E6407(2009) [PubMed] [Europe PMC] [Abstract]
  76. "Proinflammatory cytokines enhance estrogen-dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF{kappa}B cooperativity at adjacent response elements."J. Biol. Chem. 285:31100-31106(2010) [PubMed] [Europe PMC] [Abstract]
  77. "Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand."J. Mol. Med. 89:181-191(2011) [PubMed] [Europe PMC] [Abstract]
  78. "Splice isoform estrogen receptors as integral transmembrane proteins."Mol. Biol. Cell 22:4415-4423(2011) [PubMed] [Europe PMC] [Abstract]
  79. "Multiple sequence-specific DNA-binding proteins mediate estrogen receptor signaling through a tethering pathway."Mol. Endocrinol. 25:564-574(2011) [PubMed] [Europe PMC] [Abstract]
  80. "DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors."Mol. Biol. Cell 23:188-199(2012) [PubMed] [Europe PMC] [Abstract]
  81. "CBP mediates NF-kappaB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter."Mol. Cell. Biol. 32:569-575(2012) [PubMed] [Europe PMC] [Abstract]
  82. "CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha."Oncogene 32:4883-4891(2013) [PubMed] [Europe PMC] [Abstract]
  83. "Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development."Mol. Cell 56:261-274(2014) [PubMed] [Europe PMC] [Abstract]
  84. "Solution structure of the DNA-binding domain of the oestrogen receptor."Nature 348:458-461(1990) [PubMed] [Europe PMC] [Abstract]
  85. "The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements."Cell 75:567-578(1993) [PubMed] [Europe PMC] [Abstract]
  86. "Molecular basis of agonism and antagonism in the oestrogen receptor."Nature 389:753-758(1997) [PubMed] [Europe PMC] [Abstract]
  87. "Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains."Proc. Natl. Acad. Sci. U.S.A. 95:5998-6003(1998) [PubMed] [Europe PMC] [Abstract]
  88. "The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen."Cell 95:927-937(1998) [PubMed] [Europe PMC] [Abstract]
  89. "Homology model for the ligand-binding domain of the human estrogen receptor."J. Biomol. Struct. Dyn. 15:841-850(1998) [PubMed] [Europe PMC] [Abstract]
  90. "The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties."EMBO J. 8:1981-1986(1989) [PubMed] [Europe PMC] [Abstract]
  91. "A transcriptionally active estrogen receptor mutant is a novel type of dominant negative inhibitor of estrogen action."Mol. Endocrinol. 10:1519-1526(1996) [PubMed] [Europe PMC] [Abstract]
  92. "Screening for ESR mutations in breast and ovarian cancer patients."Hum. Mutat. 9:531-536(1997) [PubMed] [Europe PMC] [Abstract]
  93. "Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor alpha gene and their relationship to bone mass variation in postmenopausal Italian women."Hum. Mol. Genet. 9:2043-2050(2000) [PubMed] [Europe PMC] [Abstract]
  94. "G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells."Mol. Endocrinol. 23:1815-1826(2009) [PubMed] [Europe PMC] [Abstract]
  95. "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
  96. "Delayed puberty and estrogen resistance in a woman with estrogen receptor alpha variant."N. Engl. J. Med. 369:164-171(2013) [PubMed] [Europe PMC] [Abstract]