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Cytochrome P450 7A1 (CYP7A1)

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CYP7; CYP7-A1; CYPVII; Cholesterol 7 Alpha Hydroxylase; Cytochrome P450 Family 7 Subfamily A Polypeptide 1

Cytochrome P450 7A1 (CYP7A1)
CCC B053
HGNC 2651
MGI 106091
PubMed 21391220
RGD 2482
UniProt P22680
Wiki CYP7
Cholesterol 7 alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme in the synthesis of bile acid from cholesterol, catalyzing the formation of 7-alpha-hydroxycholesterol. CYP7A1 is a cytochrome P450 heme enzyme that oxidizes cholesterol using molecular oxygen.
It is downregulated by Sterol regulatory element binding proteins (SREBP) when plasma cholesterol levels are low. It is upregulated by the nuclear receptor LXR (liver X receptor) when cholesterol (specifically - oxysterol) levels are high. The effect of this upregulation is to increase the production of bile acids and reduce the level of cholesterol in hepatocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB053Hu01 Recombinant Cytochrome P450 7A1 (CYP7A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB053Hu01 Polyclonal Antibody to Cytochrome P450 7A1 (CYP7A1) WB; IHC; ICC; IP.
MAB053Hu22 Monoclonal Antibody to Cytochrome P450 7A1 (CYP7A1) WB; IHC; ICC; IP.
Assay Kits SEB053Hu ELISA Kit for Cytochrome P450 7A1 (CYP7A1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB053Mu01 Recombinant Cytochrome P450 7A1 (CYP7A1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB053Mu02 Recombinant Cytochrome P450 7A1 (CYP7A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB053Mu01 Polyclonal Antibody to Cytochrome P450 7A1 (CYP7A1) WB; IHC; ICC; IP.
PAB053Mu02 Polyclonal Antibody to Cytochrome P450 7A1 (CYP7A1) WB; IHC; ICC; IP.
Assay Kits SEB053Mu ELISA Kit for Cytochrome P450 7A1 (CYP7A1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB053Ra01 Recombinant Cytochrome P450 7A1 (CYP7A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB053Ra01 Polyclonal Antibody to Cytochrome P450 7A1 (CYP7A1) WB; IHC; ICC; IP.
MAB053Ra21 Monoclonal Antibody to Cytochrome P450 7A1 (CYP7A1) WB; IHC; ICC; IP.
Assay Kits SEB053Ra ELISA Kit for Cytochrome P450 7A1 (CYP7A1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structure of the gene encoding human liver cholesterol 7 alpha-hydroxylase."Biochim. Biophys. Acta 1172:147-150(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase."FEBS Lett. 268:137-140(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Polymorphisms of human cholesterol 7 alpha-hydroxylase."Biochem. Biophys. Res. Commun. 185:588-595(1992) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structure and nucleotide sequences of the human cholesterol 7 alpha-hydroxylase gene (CYP7)."Genomics 20:320-323(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene."Biochemistry 31:2539-2544(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1."Biochem. Biophys. Res. Commun. 330:395-399(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes."J. Lipid Res. 51:832-842(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of human CYP7A1."Submitted (FEB-2009) to the PDB data bank
  10. "Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."J. Hum. Genet. 48:249-270(2003) [PubMed] [Europe PMC] [Abstract]