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Superoxide Dismutase 2, Mitochondrial (SOD2)

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IPO-B; MNSOD; Mn-SOD

Superoxide Dismutase 2, Mitochondrial (SOD2)
CCC B083
HGNC 11180
MGI 98352
PubMed 12586694
RGD 3732
UniProt P04179
Wiki SOD2

SOD2, is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. This protein transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain, into hydrogen peroxide and diatomic oxygen. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), sporadic motor neuron disease, and cancer. A common polymorphism associated with greater susceptibility to various patholiges is found in the mitochondrial leader targeting sequence (Val9Ala). Mice lacking Sod2 die shortly after birth, indicating that unchecked levels of superoxide are incompatible with mammalian life.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB083Hu01 Recombinant Superoxide Dismutase 2, Mitochondrial (SOD2) Positive Control; Immunogen; SDS-PAGE; WB.
APB083Hu01 Active Superoxide Dismutase 2, Mitochondrial (SOD2) Cell culture; Activity Assays.
Antibodies MAB083Hu22 Monoclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) WB; IHC; ICC; IP.
LAB083Hu71 Biotin-Linked Polyclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) WB; IHC; ICC.
LAB083Hu81 FITC-Linked Polyclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) WB; IHC; ICC; IF.
PAB083Hu01 Polyclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) WB,IHC
Assay Kits SEB083Hu ELISA Kit for Superoxide Dismutase 2, Mitochondrial (SOD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB083Mu01 Recombinant Superoxide Dismutase 2, Mitochondrial (SOD2) Positive Control; Immunogen; SDS-PAGE; WB.
APB083Mu01 Active Superoxide Dismutase 2, Mitochondrial (SOD2) Cell culture; Activity Assays.
Antibodies PAB083Mu01 Polyclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) WB; IHC; ICC; IP.
LAB083Mu71 Biotin-Linked Polyclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) WB; IHC; ICC.
LAB083Mu81 FITC-Linked Polyclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) WB; IHC; ICC; IF.
Assay Kits SEB083Mu ELISA Kit for Superoxide Dismutase 2, Mitochondrial (SOD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB083Ra01 Recombinant Superoxide Dismutase 2, Mitochondrial (SOD2) Positive Control; Immunogen; SDS-PAGE; WB.
APB083Ra01 Active Superoxide Dismutase 2, Mitochondrial (SOD2) Cell culture; Activity Assays.
Antibodies PAB083Ra01 Polyclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) WB,IHC,ICC/IF
LAB083Ra71 Biotin-Linked Polyclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) WB; IHC; ICC.
LAB083Ra81 FITC-Linked Polyclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) WB; IHC; ICC; IF.
MAB083Ra21 Monoclonal Antibody to Superoxide Dismutase 2, Mitochondrial (SOD2) WB; IHC; ICC; IP.
Assay Kits SEB083Ra ELISA Kit for Superoxide Dismutase 2, Mitochondrial (SOD2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Synthesis and processing of the precursor for human mangano-superoxide dismutase."Biochim. Biophys. Acta 994:30-36(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Human Mn superoxide dismutase cDNA sequence."Nucleic Acids Res. 15:9076-9076(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation of cDNAs encoding human manganese superoxide dismutase."Nucleic Acids Res. 16:6224-6224(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation and characterization of complementary DNAs encoding human manganese-containing superoxide dismutase."FEBS Lett. 229:256-260(1988) [PubMed] [Europe PMC] [Abstract]
  5. "Manganese superoxide dismutase: nucleotide and deduced amino acid sequence of a cDNA encoding a new human transcript."Biochim. Biophys. Acta 1087:250-252(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Complementary DNA encoding human colon cancer manganese superoxide dismutase and the expression of its gene in human cells."Cancer Res. 51:939-943(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular structure and organization of the human manganese superoxide dismutase gene."DNA Cell Biol. 13:1127-1136(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "The primary structure of human liver manganese superoxide dismutase."J. Biol. Chem. 259:12595-12601(1984) [PubMed] [Europe PMC] [Abstract]
  12. "The human myocardial two-dimensional gel protein database: update 1994."Electrophoresis 15:1459-1465(1994) [PubMed] [Europe PMC] [Abstract]
  13. "The major protein expression profile and two-dimensional protein database of human heart."Electrophoresis 16:1160-1169(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2."Electrophoresis 18:588-598(1997) [PubMed] [Europe PMC] [Abstract]
  15. "Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite."Arch. Biochem. Biophys. 366:82-88(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging."Am. J. Physiol. 290:H2220-H2227(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "KRIT1 regulates the homeostasis of intracellular reactive oxygen species."PLoS ONE 5:E11786-E11786(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles."Cell 71:107-118(1992) [PubMed] [Europe PMC] [Abstract]
  22. "Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface."Biochemistry 35:4287-4297(1996) [PubMed] [Europe PMC] [Abstract]
  23. "Probing the active site of human manganese superoxide dismutase: the role of glutamine 143."Biochemistry 37:4731-4739(1998) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34."Biochemistry 37:4722-4730(1998) [PubMed] [Europe PMC] [Abstract]
  25. "Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis."Biochemistry 39:7131-7137(2000) [PubMed] [Europe PMC] [Abstract]
  26. "Kinetic analysis of product inhibition in human manganese superoxide dismutase."Biochemistry 40:12051-12058(2001) [PubMed] [Europe PMC] [Abstract]
  27. "Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis."Biochemistry 48:3417-3424(2009) [PubMed] [Europe PMC] [Abstract]
  28. "The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients."J. Hum. Genet. 48:138-141(2003) [PubMed] [Europe PMC] [Abstract]