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Chemokine C-C-Motif Ligand 14 (CCL14)

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SCYA14; HCC-1; HCC-3; NCC-2; SCYL2; CKb1; MCIF; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 14

Chemokine C-C-Motif Ligand 14 (CCL14)
CCC B122
HGNC 10612
UniProt Q16627
Wiki CCL14

Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4.

This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut.CCL14 activates monocytes, but does not induce their chemotaxis. Human CCL14 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB122Hu01 Recombinant Chemokine C-C-Motif Ligand 14 (CCL14) Positive Control; Immunogen; SDS-PAGE; WB.
RPB122Hu02 Recombinant Chemokine C-C-Motif Ligand 14 (CCL14) Positive Control; Immunogen; SDS-PAGE; WB.
APB122Hu01 Active Chemokine C-C-Motif Ligand 14 (CCL14) Cell culture; Activity Assays.
Antibodies PAB122Hu01 Polyclonal Antibody to Chemokine C-C-Motif Ligand 14 (CCL14) WB; IHC; ICC; IP.
MAB122Hu22 Monoclonal Antibody to Chemokine C-C-Motif Ligand 14 (CCL14) WB; IHC; ICC; IP.
LAB122Hu71 Biotin-Linked Polyclonal Antibody to Chemokine C-C-Motif Ligand 14 (CCL14) WB; IHC; ICC.
PAB122Hu02 Polyclonal Antibody to Chemokine C-C-Motif Ligand 14 (CCL14) WB; IHC; ICC; IP.
Assay Kits SEB122Hu ELISA Kit for Chemokine C-C-Motif Ligand 14 (CCL14) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB122Hu CLIA Kit for Chemokine C-C-Motif Ligand 14 (CCL14) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine C-C-Motif Ligand 14 (CCL14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine C-C-Motif Ligand 14 (CCL14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine C-C-Motif Ligand 14 (CCL14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine C-C-Motif Ligand 14 (CCL14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-C-Motif Ligand 14 (CCL14) ELISA Kit Customized Service Offer
  1. "HCC-1, a novel chemokine from human plasma."J. Exp. Med. 183:295-299(1996) [PubMed] [Europe PMC] [Abstract]
  2. "HCC-2, a human chemokine: gene structure, expression pattern, and biological activity."Proc. Natl. Acad. Sci. U.S.A. 95:6308-6313(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Posttranslationally processed forms of the human chemokine HCC-1."Biochemistry 39:10799-10805(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties."J. Exp. Med. 192:1501-1508(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Structural and functional characterization of CC chemokine CCL14."Biochemistry 46:10008-10015(2007) [PubMed] [Europe PMC] [Abstract]