Actin Alpha 1, Cardiac Muscle (ACTC1)

[Edit]

ACTC; CMD1R; CMD1-R; ACT-a1

Actin Alpha 1, Cardiac Muscle (ACTC1)
Actin, alpha cardiac muscle 1 is a protein encoded by the ACTC1 gene.Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others.
The protein encoded by this gene belongs to the actin family which is composed of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB341Hu01Recombinant Actin Alpha 1, Cardiac Muscle (ACTC1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB341Hu51Polyclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1)WB, ICC, IHC-P, IHC-F, ELISA
PAB341Hu01Polyclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1)WB, ICC, IHC-P, IHC-F, ELISA
CAB341Hu01Anti-Actin Alpha 1, Cardiac Muscle (ACTC1) Polyclonal AntibodyLoading Control of WB
CAB341Hu21Anti-Actin Alpha 1, Cardiac Muscle (ACTC1) Monoclonal AntibodyLoading Control of WB
Assay Kitsn/aCLIA Kit for Actin Alpha 1, Cardiac Muscle (ACTC1)CLIA Kit Customized Service Offer
n/aELISA Kit for Actin Alpha 1, Cardiac Muscle (ACTC1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Actin Alpha 1, Cardiac Muscle (ACTC1)Recombinant Protein Customized Service Offer
AntibodiesPAB341Mu51Polyclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Actin Alpha 1, Cardiac Muscle (ACTC1)CLIA Kit Customized Service Offer
n/aELISA Kit for Actin Alpha 1, Cardiac Muscle (ACTC1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Actin Alpha 1, Cardiac Muscle (ACTC1)Recombinant Protein Customized Service Offer
AntibodiesPAB341Ra51Polyclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Actin Alpha 1, Cardiac Muscle (ACTC1)CLIA Kit Customized Service Offer
n/aELISA Kit for Actin Alpha 1, Cardiac Muscle (ACTC1)ELISA Kit Customized Service Offer
  1. "Molecular structure and evolutionary origin of human cardiac muscle actin gene."Proc. Natl. Acad. Sci. U.S.A. 79:5901-5905(1982) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "ALKBH4-dependent demethylation of actin regulates actomyosin dynamics."Nat. Commun. 4:1832-1832(2013) [PubMed] [Europe PMC] [Abstract]
  4. "Actin mutations in dilated cardiomyopathy, a heritable form of heart failure."Science 280:750-752(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy."J. Clin. Invest. 103:R39-R43(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy."J. Mol. Cell. Cardiol. 32:1687-1694(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Clinical and genetic characteristics of alpha cardiac actin gene mutations in hypertrophic cardiomyopathy."J. Med. Genet. 41:E10-E10(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Alpha-cardiac actin mutations produce atrial septal defects."Hum. Mol. Genet. 17:256-265(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Shared genetic causes of cardiac hypertrophy in children and adults."N. Engl. J. Med. 358:1899-1908(2008) [PubMed] [Europe PMC] [Abstract]