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Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF)

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HB-EGF; DTR; DTS; DTSF; HEGFL; Diphtheria Toxin Receptor; Proheparin-binding EGF-like growth factor; Diphtheria toxin receptor

Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF)
CCC B479
HGNC 3059
MGI 96070
PubMed 12112577
RGD 2526
UniProt Q99075
Wiki HBEGF

  • Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function.

  • Diphtheria toxin inhibits protein synthesis in eukaryotic cells by catalyzing inactivation of elongation factor-2 (EF2). Entry of toxin into cells is dependent on binding to the cell surface.

  • Mice and rats are resistant to diphtheria toxin, and the resistance extends to cultured cells. Mouse-human hybrid cells are sensitive to diphtheria toxin. Creagan et al. (1975) showed that sensitivity is determined by human chromosome 5, which presumably carries a gene for a receptor for toxin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB479Hu01 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
APB479Hu01 Active Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Cell culture; Activity Assays.
EPB479Hu61 Eukaryotic Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
APB479Hu61 Active Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Cell culture; Activity Assays.
Antibodies PAB479Hu01 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB,IHC
MAB479Hu22 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
LAB479Hu71 Biotin-Linked Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC.
MAB479Hu21 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
MAB479Hu23 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
MAB479Hu24 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
Assay Kits SEB479Hu ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB479Hu CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB479Mu01 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
RPB479Mu02 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB479Mu01 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
PAB479Mu02 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
Assay Kits SEB479Mu ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB479Mu CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB479Ra01 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB479Ra01 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
MAB479Ra21 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
Assay Kits SEB479Ra ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB479Ra CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Chemiluminescent immunoassay for Antigen Detection.
  1. "A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF."Science 251:936-939(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein."J. Biol. Chem. 267:6205-6212(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity."J. Biol. Chem. 270:1015-1019(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation."EMBO J. 16:1268-1278(1997) [PubMed] [Europe PMC] [Abstract]
  8. "ErbB and HB-EGF signaling in heart development and function."Cell Struct. Funct. 31:1-14(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  10. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor."Mol. Cell 1:67-78(1997) [PubMed] [Europe PMC] [Abstract]