Salivary Alpha Amylase (AMY1A)
[Edit]AMY1; AMY1B; AMY1C; Ptyalin; 1,4-alpha-D-glucan glucanohydrolase 1
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The alpha-amylases hydrolyze alpha-1,4-glucoside bonds in polymers of glucose units. Kamaryt and Laxova found 2 amylase isoenzymes in serum, one produced by the salivary gland and the second by the pancreas. In 11 of 120 children, a duplication of pancreatic enzyme band was found on starch gel electrophoresis and in each case 1 parent also showed the duplication. In the mouse the salivary and pancreatic amylases are determined by genes at closely linked loci.
The separate loci in the human were designated AMY1 (salivary) and AMY2 (pancreatic). Polymorphism of both the salivary and the pancreatic serum amylases has been demonstrated in man. Ward et al. (1971) studied amylase in saliva and identified electrophoretic variants.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB482Mu01 | Recombinant Salivary Alpha Amylase (AMY1A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB482Mu01 | Polyclonal Antibody to Salivary Alpha Amylase (AMY1A) | WB; IHC; ICC; IP. |
| LAB482Mu71 | Biotin-Linked Polyclonal Antibody to Salivary Alpha Amylase (AMY1A) | WB; IHC; ICC. | |
| LAB482Mu81 | FITC-Linked Polyclonal Antibody to Salivary Alpha Amylase (AMY1A) | WB; IHC; ICC; IF. | |
| MAB482Mu21 | Monoclonal Antibody to Salivary Alpha Amylase (AMY1A) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Salivary Alpha Amylase (AMY1A) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Salivary Alpha Amylase (AMY1A) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB482Ra01 | Recombinant Salivary Alpha Amylase (AMY1A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB482Ra01 | Polyclonal Antibody to Salivary Alpha Amylase (AMY1A) | WB; IHC; ICC; IP. |
| MAB482Ra21 | Monoclonal Antibody to Salivary Alpha Amylase (AMY1A) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB482Ra | ELISA Kit for Salivary Alpha Amylase (AMY1A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Primary structure of human salivary alpha-amylase gene."Gene 41:299-304(1986) [PubMed] [Europe PMC] [Abstract]
- "Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases."Gene 28:263-270(1984) [PubMed] [Europe PMC] [Abstract]
- ErratumGene 50:371-372(1986)
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Concerted evolution of human amylase genes."Mol. Cell. Biol. 8:1197-1205(1988) [PubMed] [Europe PMC] [Abstract]
- "Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1."Mol. Biol. Med. 4:145-155(1987) [PubMed] [Europe PMC] [Abstract]
- "Electrophoretic characterization of posttranslational modifications of human parotid salivary alpha-amylase."Electrophoresis 12:74-79(1991) [PubMed] [Europe PMC] [Abstract]
- "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
- "Structure of human salivary alpha-amylase at 1.6-A resolution: implications for its role in the oral cavity."Acta Crystallogr. D 52:435-446(1996) [PubMed] [Europe PMC] [Abstract]
- "Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase."J. Mol. Biol. 325:1061-1076(2003) [PubMed] [Europe PMC] [Abstract]