≡

Serpin A10 (SERPINA10)

[Edit]

PZI; ZPI; Serine(Cysteine)Proteinase Inhibitor,Clade A(Alpha-1 Antiproteinase,Antitrypsin)Member 10; Protein Z-Related Protease Inhibitor; Protein Z Dependent Protease Inhibitor

Serpin A10 (SERPINA10)
CCC C010
HGNC 15996
MGI 2667725
PubMed 23963134
RGD 621220
UniProt Q9UK55
Wiki ZPI

Protein Z-dependent protease inhibitor is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another circulating protein, to function properly, but this only applies to its inhibition of factor X.

It is about 72 kDa heavy and 444 amino acids large. It is produced by the liver.Water et al. found deficiency of ZPI in 4.4% of a cohort of patients with thrombophilia (a tendency to thrombosis).Han et al. first described ZPI in 1998. The same group further characterised it in 2000.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC010Hu01 Recombinant Serpin A10 (SERPINA10) Positive Control; Immunogen; SDS-PAGE; WB.
RPC010Hu02 Recombinant Serpin A10 (SERPINA10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC010Hu01 Polyclonal Antibody to Serpin A10 (SERPINA10) WB; IHC; ICC; IP.
MAC010Hu22 Monoclonal Antibody to Serpin A10 (SERPINA10) WB; IHC
MAC010Hu21 Monoclonal Antibody to Serpin A10 (SERPINA10) WB
MAC010Hu23 Monoclonal Antibody to Serpin A10 (SERPINA10) WB; IHC; ICC; IP.
MAC010Hu27 Monoclonal Antibody to Serpin A10 (SERPINA10) WB; IHC; ICC; IP.
MAC010Hu25 Monoclonal Antibody to Serpin A10 (SERPINA10) WB; IHC; ICC; IP.
MAC010Hu29 Monoclonal Antibody to Serpin A10 (SERPINA10) WB; IHC; ICC; IP.
Assay Kits SEC010Hu ELISA Kit for Serpin A10 (SERPINA10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC010Mu01 Recombinant Serpin A10 (SERPINA10) Positive Control; Immunogen; SDS-PAGE; WB.
RPC010Mu02 Recombinant Serpin A10 (SERPINA10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC010Mu01 Polyclonal Antibody to Serpin A10 (SERPINA10) WB; IHC; ICC; IP.
PAC010Mu02 Polyclonal Antibody to Serpin A10 (SERPINA10) WB; IHC; ICC; IP.
Assay Kits SEC010Mu ELISA Kit for Serpin A10 (SERPINA10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC010Ra01 Recombinant Serpin A10 (SERPINA10) Positive Control; Immunogen; SDS-PAGE; WB.
RPC010Ra02 Recombinant Serpin A10 (SERPINA10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC010Ra01 Polyclonal Antibody to Serpin A10 (SERPINA10) WB; IHC; ICC; IP.
PAC010Ra02 Polyclonal Antibody to Serpin A10 (SERPINA10) WB; IHC; ICC; IP.
LAC010Ra71 Biotin-Linked Polyclonal Antibody to Serpin A10 (SERPINA10) WB; IHC; ICC.
LAC010Ra81 FITC-Linked Polyclonal Antibody to Serpin A10 (SERPINA10) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Serpin A10 (SERPINA10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serpin A10 (SERPINA10) ELISA Kit Customized Service Offer
  1. "The protein Z-dependent protease inhibitor is a serpin."Biochemistry 38:11073-11078(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation of a protein Z-dependent plasma protease inhibitor."Proc. Natl. Acad. Sci. U.S.A. 95:9250-9255(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the protein Z-dependent protease inhibitor."Blood 96:3049-3055(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of the heparin-binding site of the protein z-dependent protease inhibitor."Biochemistry 51:4078-4085(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X."Blood 114:3662-3667(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa."J. Biol. Chem. 285:20399-20409(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of mutations in SLC24A4, encoding a potassium-dependent sodium/calcium exchanger, as a cause of amelogenesis imperfecta."Am. J. Hum. Genet. 92:307-312(2013) [PubMed] [Europe PMC] [Abstract]