Collagen Type XVIII (COL18)

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COL18-A1; COL18A1; KNO; Endostatin; Collagen Alpha-1(XVIII)Chain

Collagen Type XVIII (COL18)

Collagen, type XVIII, alpha 1, also known as COL18A1,alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains.

The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC134Hu01 Recombinant Collagen Type XVIII (COL18) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC134Hu01 Polyclonal Antibody to Collagen Type XVIII (COL18) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Collagen Type XVIII (COL18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type XVIII (COL18) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC134Mu01 Recombinant Collagen Type XVIII (COL18) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC134Mu01 Polyclonal Antibody to Collagen Type XVIII (COL18) WB; IHC; ICC; IP.
LAC134Mu71 Biotin-Linked Polyclonal Antibody to Collagen Type XVIII (COL18) WB; IHC; ICC.
LAC134Mu81 FITC-Linked Polyclonal Antibody to Collagen Type XVIII (COL18) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Collagen Type XVIII (COL18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type XVIII (COL18) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC134Ra01 Recombinant Collagen Type XVIII (COL18) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC134Ra01 Polyclonal Antibody to Collagen Type XVIII (COL18) WB; IHC; ICC; IP.
LAC134Ra81 FITC-Linked Polyclonal Antibody to Collagen Type XVIII (COL18) WB; IHC; ICC; IF.
LAC134Ra71 Biotin-Linked Polyclonal Antibody to Collagen Type XVIII (COL18) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Collagen Type XVIII (COL18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type XVIII (COL18) ELISA Kit Customized Service Offer
  1. "Complete primary structure of two variant forms of human type XVIII collagen and tissue-specific differences in the expression of the corresponding transcripts."Matrix Biol. 16:319-328(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the human type XVIII collagen gene and proteolytic processing and tissue location of the variant containing a frizzled motif."Matrix Biol. 22:427-442(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to mouse chromosome 10 and human chromosome 21."Genomics 19:494-499(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Inhibition effect in vitro of purified endostatin expressed in Pichia pastoris."Sheng Wu Gong Cheng Xue Bao 17:278-282(2001) [PubMed] [Europe PMC] [Abstract]
  7. "No evidence for locus heterogeneity in Knobloch syndrome."J. Med. Genet. 50:565-566(2013) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Zinc-dependent dimers observed in crystals of human endostatin."Proc. Natl. Acad. Sci. U.S.A. 95:10443-10448(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure."Hum. Mol. Genet. 9:2051-2058(2000) [PubMed] [Europe PMC] [Abstract]
  11. "A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma."Cancer Res. 61:7375-7378(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Knobloch syndrome: novel mutations in COL18A1, evidence for genetic heterogeneity, and a functionally impaired polymorphism in endostatin."Hum. Mutat. 23:77-84(2004) [PubMed] [Europe PMC] [Abstract]
  13. "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]