Left/Right Determination Factor 1 (LEFTY1)
[Edit]LEFTY-B; LEFTYB; LEFT-B; LEFTB; Left Right Determination Factor B
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Vertebrates exhibit numerous left-right (L-R) asymmetries, such as the position of the heart and spleen on the left side. L-R polarity is determined early during development, around the presomite stage in mammals. Several genes have been shown to be expressed asymmetrically relative to the L-R axis. Meno et al. (1996, 1997) identified 2 transforming growth factor-beta-related genes, Lefty1 and Lefty2, that are expressed on the left side of developing mouse embryos.Kosaki et al. (1999) characterized 2 homologs of the murine Lefty1 and Lefty2 genes, which they designated LEFTY B and LEFTY A, respectively. Both genes encode proteins with 366 amino acids. The deduced amino acid sequences of LEFTY B and LEFTY A are more similar to each other than to mouse Lefty1 or Lefty2.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC175Mu01 | Recombinant Left/Right Determination Factor 1 (LEFTY1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC175Mu02 | Recombinant Left/Right Determination Factor 1 (LEFTY1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC175Mu01 | Polyclonal Antibody to Left/Right Determination Factor 1 (LEFTY1) | WB; IHC; ICC; IP. |
| LAC175Mu81 | FITC-Linked Polyclonal Antibody to Left/Right Determination Factor 1 (LEFTY1) | WB; IHC; ICC; IF. | |
| LAC175Mu71 | Biotin-Linked Polyclonal Antibody to Left/Right Determination Factor 1 (LEFTY1) | WB; IHC; ICC. | |
| PAC175Mu02 | Polyclonal Antibody to Left/Right Determination Factor 1 (LEFTY1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC175Mu | ELISA Kit for Left/Right Determination Factor 1 (LEFTY1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC175Mu | CLIA Kit for Left/Right Determination Factor 1 (LEFTY1) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC175Ra01 | Recombinant Left/Right Determination Factor 1 (LEFTY1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC175Ra01 | Polyclonal Antibody to Left/Right Determination Factor 1 (LEFTY1) | WB; IHC; ICC; IP. |
| LAC175Ra81 | FITC-Linked Polyclonal Antibody to Left/Right Determination Factor 1 (LEFTY1) | WB; IHC; ICC; IF. | |
| LAC175Ra71 | Biotin-Linked Polyclonal Antibody to Left/Right Determination Factor 1 (LEFTY1) | WB; IHC; ICC. | |
| MAC175Ra21 | Monoclonal Antibody to Left/Right Determination Factor 1 (LEFTY1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC175Ra | ELISA Kit for Left/Right Determination Factor 1 (LEFTY1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC175Ra | CLIA Kit for Left/Right Determination Factor 1 (LEFTY1) | Chemiluminescent immunoassay for Antigen Detection. |
- "Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development."Am. J. Hum. Genet. 64:712-721(1999) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]