Osteoglycin (OGN)

[Edit]

OIF; SLRR3A; Mimecan Proteoglycan; Osteoinductive Factor

Osteoglycin (OGN)
Osteoglycin is a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy.
The human gene encodes a predicted 298-amino acid precursor protein that is processed into a 103-amino acid mature protein with 96% identity to the bovine protein. Northern blot analysis detected 3 OGN mRNAs exclusively in 2 human osteosarcoma cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC688Hu01 Recombinant Osteoglycin (OGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC688Hu01 Polyclonal Antibody to Osteoglycin (OGN) WB; IHC; ICC; IP.
MAC688Hu22 Monoclonal Antibody to Osteoglycin (OGN) WB; IHC; ICC; IP.
LAC688Hu71 Biotin-Linked Polyclonal Antibody to Osteoglycin (OGN) WB; IHC; ICC.
Assay Kits SEC688Hu ELISA Kit for Osteoglycin (OGN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC688Mu01 Recombinant Osteoglycin (OGN) Positive Control; Immunogen; SDS-PAGE; WB.
RPC688Mu02 Recombinant Osteoglycin (OGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC688Mu01 Polyclonal Antibody to Osteoglycin (OGN) WB; IHC; ICC; IP.
LAC688Mu71 Biotin-Linked Polyclonal Antibody to Osteoglycin (OGN) WB; IHC; ICC.
PAC688Mu02 Polyclonal Antibody to Osteoglycin (OGN) WB; IHC; ICC; IP.
Assay Kits SEC688Mu ELISA Kit for Osteoglycin (OGN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC688Ra01 Recombinant Osteoglycin (OGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC688Ra01 Polyclonal Antibody to Osteoglycin (OGN) WB; IHC; ICC; IP.
LAC688Ra71 Biotin-Linked Polyclonal Antibody to Osteoglycin (OGN) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Osteoglycin (OGN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Osteoglycin (OGN) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a novel bone-forming compound: osteoinductive factor."DNA Cell Biol. 9:303-309(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in KERA, encoding keratocan, cause cornea plana."Nat. Genet. 25:91-95(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon."J. Biol. Chem. 274:18693-18701(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]