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Cathepsin V (CTSV)

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CTS-L2; CTSL2; CATL2; CTSU; CTS-V; Cathepsin L2

Cathepsin V (CTSV)
CCC C970
HGNC 2538
MGI 88564
PubMed 10029531
UniProt O60911
Wiki Cathepsin_L2

Cathepsin L2 is a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.

The predicted 334-amino acid protein was designated cathepsin L2 because it shared 78% sequence identity with cathepsin L. Cathepsin L2 contains a 17-amino acid signal sequence and a 96-amino acid proregion. Recombinant protein displayed cysteine proteinase activity in vitro, with substrate specificity similar to that of cathepsin L. Northern blot analysis revealed that cathepsin L2 is expressed as a 1.8-kb mRNA predominantly in thymus and testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC970Hu01 Recombinant Cathepsin V (CTSV) Positive Control; Immunogen; SDS-PAGE; WB.
APC970Hu01 Active Cathepsin V (CTSV) Cell culture; Activity Assays.
Antibodies PAC970Hu01 Polyclonal Antibody to Cathepsin V (CTSV) WB; IHC; ICC; IP.
MAC970Hu22 Monoclonal Antibody to Cathepsin V (CTSV) WB; IHC; ICC; IP.
Assay Kits SEC970Hu ELISA Kit for Cathepsin V (CTSV) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cathepsin V (CTSV) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cathepsin V (CTSV) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cathepsin V (CTSV) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cathepsin V (CTSV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cathepsin V (CTSV) ELISA Kit Customized Service Offer
  1. "Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas."Cancer Res. 58:1624-1630(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium."Invest. Ophthalmol. Vis. Sci. 39:1789-1796(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization."Biochemistry 38:2377-2385(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization and chromosomal localization of the human cathepsin L2 gene."DNA Res. 6:137-140(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Determination of cathepsin V activity and intracellular trafficking by N-glycosylation."FEBS Lett. 586:3601-3607(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of human cathepsin V."Biochemistry 39:12543-12551(2000) [PubMed] [Europe PMC] [Abstract]
  10. ErratumBiochemistry 40:4200-4200(2001)