Lamin A/C (LMNA)

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CDCD1; CMD1A; CMT2B1; EMD2; FPL; FPLD; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; PRO1; Cardiomyopathy Dilated 1A; Limb Girdle Muscular Dystrophy 1B; Progeria 1

Lamin A/C (LMNA)
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution.
Lamin A is targeted to the nuclear membrane by an isoprenyl group but it is cleaved shortly after arriving at the membrane. It stays associated with the membrane through protein-protein interactions of itself and other membrane associated proteins, such as LAP1. Depolymerization of the nuclear lamins leads to disintegration of the nuclear envelope. Transfection experiments demonstrate that phosphorylation of human lamin A is required for lamin depolymerization, and thus for disassembly of the nuclear envelope, which normally occurs early in mitosis.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPF550Hu01Recombinant Lamin A/C (LMNA)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAF550Hu01Polyclonal Antibody to Lamin A/C (LMNA)WB, ICC, IHC-P, IHC-F, ELISA
MAF550Hu21Monoclonal Antibody to Lamin A/C (LMNA)WB, ICC, IHC-P, IHC-F, ELISA
CAF550Hu22Anti-Lamin A/C (LMNA) Monoclonal AntibodyLoading Control of WB.
CAF550Hu01Anti-Lamin A/C (LMNA) Polyclonal AntibodyLoading Control of WB.
Assay KitsSEF550HuELISA Kit for Lamin A/C (LMNA)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPF550Mu01Recombinant Lamin A/C (LMNA)SDS-PAGE; WB; ELISA; IP.
RPF550Mu02Recombinant Lamin A/C (LMNA)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAF550Mu01Polyclonal Antibody to Lamin A/C (LMNA)WB, ICC, IHC-P, IHC-F, ELISA
PAF550Mu02Polyclonal Antibody to Lamin A/C (LMNA)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEF550MuELISA Kit for Lamin A/C (LMNA)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPF550Ra01Recombinant Lamin A/C (LMNA)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAF550Ra01Polyclonal Antibody to Lamin A/C (LMNA)WB, ICC, IHC-P, IHC-F, ELISA
MAF550Ra21Monoclonal Antibody to Lamin A/C (LMNA)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEF550RaELISA Kit for Lamin A/C (LMNA)Enzyme-linked immunosorbent assay for Antigen Detection
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  82. "A novel homozygous Ala529Val LMNA mutation in Turkish patients with mandibuloacral dysplasia."J. Clin. Endocrinol. Metab. 90:5259-5264(2005) [PubMed] [Europe PMC] [Abstract]
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  87. "Mutations of the LMNA gene can mimic autosomal dominant proximal spinal muscular atrophy."Neurogenetics 8:137-142(2007) [PubMed] [Europe PMC] [Abstract]
  88. "New metabolic phenotypes in laminopathies: LMNA mutations in patients with severe metabolic syndrome."J. Clin. Endocrinol. Metab. 92:4835-4844(2007) [PubMed] [Europe PMC] [Abstract]
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  92. "Comprehensive mutation scanning of LMNA in 268 patients with lone atrial fibrillation."Am. J. Cardiol. 103:1426-1428(2009) [PubMed] [Europe PMC] [Abstract]
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  98. "Mutations in LMNA modulate the lamin A--Nesprin-2 interaction and cause LINC complex alterations."PLoS ONE 8:E71850-E71850(2013) [PubMed] [Europe PMC] [Abstract]
  99. "LMNA gene mutation as a model of cardiometabolic dysfunction: from genetic analysis to treatment response."Diabetes Metab. 40:224-228(2014) [PubMed] [Europe PMC] [Abstract]