High Temperature Requirement Factor A1 (HTRA1)

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HtrA; L56; ORF480; PRSS11; HtrA Serine Peptidase 1; Protease,Serine,11; IGFBP5-Protease; High-temperature requirement A serine peptidase 1

High Temperature Requirement Factor A1 (HTRA1)
HTRA1 encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.The deduced 480-amino acid protein is 98% identical to the cow, guinea pig, and rabbit proteins. It contains an N terminus homologous to MAC25 (IGFBP7) with a conserved Kazal-type serine protease inhibitor motif, as well as a C-terminal PDZ domain. Semiquantitative RT-PCR and immunoblot analyses showed an approximately 7-fold increase of PRSS11 in osteoarthritis cartilage compared with controls. Functional and mutational analyses indicated that PRS11 is a serine protease dependent on the presence of a serine at position 328.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL604Hu01 Recombinant High Temperature Requirement Factor A1 (HTRA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL604Hu01 Polyclonal Antibody to High Temperature Requirement Factor A1 (HTRA1) WB; IHC; ICC; IP.
LAL604Hu71 Biotin-Linked Polyclonal Antibody to High Temperature Requirement Factor A1 (HTRA1) WB; IHC; ICC.
Assay Kits SEL604Hu ELISA Kit for High Temperature Requirement Factor A1 (HTRA1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCL604Hu CLIA Kit for High Temperature Requirement Factor A1 (HTRA1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant High Temperature Requirement Factor A1 (HTRA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to High Temperature Requirement Factor A1 (HTRA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to High Temperature Requirement Factor A1 (HTRA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for High Temperature Requirement Factor A1 (HTRA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for High Temperature Requirement Factor A1 (HTRA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant High Temperature Requirement Factor A1 (HTRA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to High Temperature Requirement Factor A1 (HTRA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to High Temperature Requirement Factor A1 (HTRA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for High Temperature Requirement Factor A1 (HTRA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for High Temperature Requirement Factor A1 (HTRA1) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant High Temperature Requirement Factor A1 (HTRA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to High Temperature Requirement Factor A1 (HTRA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to High Temperature Requirement Factor A1 (HTRA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for High Temperature Requirement Factor A1 (HTRA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for High Temperature Requirement Factor A1 (HTRA1) ELISA Kit Customized Service Offer

Organism species: Escherichia coli

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL604Co01 Recombinant High Temperature Requirement Factor A1 (HTRA1) Positive Control; Immunogen; SDS-PAGE; WB.
RPL604Co02 Recombinant High Temperature Requirement Factor A1 (HTRA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL604Co01 Polyclonal Antibody to High Temperature Requirement Factor A1 (HTRA1) WB; IHC; ICC; IP.
PAL604Co02 Polyclonal Antibody to High Temperature Requirement Factor A1 (HTRA1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for High Temperature Requirement Factor A1 (HTRA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for High Temperature Requirement Factor A1 (HTRA1) ELISA Kit Customized Service Offer
  1. "Primary structure of a putative serine protease specific for IGF-binding proteins."FEBS Lett. 398:187-192(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage."J. Biol. Chem. 273:34406-34412(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The serine protease HtrA1 is upregulated in the human placenta during pregnancy."J. Histochem. Cytochem. 52:885-892(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The role of human HtrA1 in arthritic disease."J. Biol. Chem. 281:6124-6129(2006) [PubMed] [Europe PMC] [Abstract]
  5. "HTRA1 promoter polymorphism in wet age-related macular degeneration."Science 314:989-992(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration."Science 314:992-993(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein."Mol. Cancer Res. 8:1248-1260(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Solution structure of the PDZ-domain of human protease HTRA 1 precursor."Submitted (APR-2008) to the PDB data bank
  9. "Substrate-induced remodeling of the active site regulates human HTRA1 activity."Nat. Struct. Mol. Biol. 18:386-388(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease." N. Engl. J. Med. 360:1729-1739(2009) [PubMed] [Europe PMC] [Abstract]