Biotin-Linked Monoclonal Antibody to Corticosterone (Cort)



The antibody is a mouse monoclonal antibody raised against Cort. It has been selected for its ability to recognize Cort in immunohistochemical staining and western blotting.


Western blotting: 0.2-2µg/mL;1:500-5000
Immunohistochemistry: 5-20µg/mL;1:50-200
Immunocytochemistry: 5-20µg/mL;1:50-200
Optimal working dilutions must be determined by end user.


Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.


The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.



Magazine Citations
Respir Res. Intracerebroventricular injection of leukotriene B4 attenuates antigen-induced asthmatic response via BLT1 receptor stimulating HPA-axis in sensitized rats. PubMed: 20403205
Natural Product Sciences Effects of Gypenosides on Acute Stress in Mice Papersearch: Source
Neuropeptides.? Role of adrenomedullin in the cerebrospinal fluid-contacting nucleus in the modulation of immobilization stress Pubmed:25911494
EXPERIMENTAL & CLINICAL CARDIOLOGY Sick Sinus Syndrome May Attribute to the Decrease of ?±-klotho Protein in Mice Com:Source
Journal of Pharmacological Sciences Organ-Specific Activation of the Gastric Branch of the Efferent Vagus Nerve by Ghrelin in Urethane-Anesthetized Rats Pubmed:24366191
Toxicology Letters Regulation of corticosterone secretion is modified by PFOS exposure at different levels of the hypothalamic–pituitary–adrenal axis in adult male rats Pubmed:24440345
Stress. Restraint stress alters immune parameters and induces oxidative stress in the mouse uterus during embryo implantation Pubmed:25238024
Int J Clin Exp Med Diabetes alters the blood glucose response to ketamine in streptozotocin-diabetic rats PubMed: 26379948
Pakistan Veterinary Journal Trivalent Chromium Attenuated Corticosterone Secretion and Actions in Adrenocorticotropic Hormone-Stimulated Rats In_Press: 15-058.Pdf
BMC Ameliorating effects of gypenosides on chronic stress-induced anxiety disorders in mice PubMed: 26370834
Behav Brain Res Rats with differential self-grooming expression in the elevated plus-maze do not differ in anxiety-related behaviors PubMed: 26142783
Archives of Physiology and Biochemistry Improvement of oral contraceptive-induced glucose dysreCavia (Guinea pig )lation and dyslipidemia by valproic acid is independent of circulating corticosterone Pubmed:26855320
Archives of Physiology and Biochemistry Activation of cardiac renin–angiotensin system and plasminogen activator inhibitor-1 gene expressions in oral contraceptive-induced cardiometabolic disorder Pubmed:26934364
Neuroscience Letters Electroacupuncture reCavia (Guinea pig )late hypothalamic–pituitary–adrenal axis and enhance hippocampal serotonin system in a rat model of depression Pubmed:26773866
Neural Regeneration Research Moxibustion upreCavia (Guinea pig )lates hippocampal progranulin expression. Pubmed:27212922
Environmental Science and Pollution Research Lycopene ameliorates atrazine-induced oxidative damage in adrenal cortex of male rats by activation of the Nrf2/HO-1 pathway Pubmed:27102619
Eur Neuropsychopharmacol Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats Pubmed:26853763
experimental brain research Dopamine D2-like receptors modulate freezing response, but not the activation of HPA axis, during the expression of conditioned fear. pubmed:27766352
brain research bulletin Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus. pubmed:28161195
Neurochemical Research  Effects of (-)-Sesamin on Chronic Stress-Induced Anxiety Disorders in Mice pubmed:27995494
Journal of Molecular Histology Role of serotonin in the intestinal mucosal epithelium barrier in weaning mice undergoing stress-induced diarrhea pubmed:29260435
Psychosomatic Medicine The Role of Psychological Stress on Heart Autophagy in Mice With Heart Failure pubmed:28691995
Scientific Reports COMMUNICATIONS Environmental perturbation of the circadian clock during pregnancy leads to transgenerational mood disorder-like behaviors in mice pubmed:28974783
BMC Gastroenterology Role of serotonin on the intestinal mucosal immune response to stress-induced diarrhea in weaning mice pubmed:28633646
biorxiv Anxiety-like but not despair-like behaviors are further aggravated by chronic mild stress in the early stages of APPswe/PS1dE9 transgenic mice
Frontiers in Molecular Neuroscience Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis. pubmed:28959186
Biochemical Pharmacology Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in naïve and Aβ-treated female rats Pubmed:30028991
Toxicological Sciences Impact of Perfluorooctane Sulfonate on Reproductive Ability of Female Mice through Suppression of Estrogen Receptor a-Activated Kisspeptin Neurons 10.1093:toxsci
Nutrition Multigenerational effects of dietary macronutrients intake on the metabolic phenotype of male Wistar rats 10.1016:j.nut.2018.06.008
Behavioural Brain Research Depressive-and anxiety-like phenotypes in young adult APPSwe/PS1dE9 transgenic mice with insensitivity to chronic mild stress Pubmed:30012417
Stress Blockade of AT1 type receptors for angiotensin II prevents cardiac microvascular fibrosis induced by chronic stress in Sprague–Dawley rats Pubmed:29676198
Inflammation Differential Effects of Brain Death on Rat Microcirculation and Intestinal Inflammation: Female Male Pubmed:29737476
Respiratory physiology & neurobiology Curcumin attenuates chronic intermittent hypoxia-induced brain injuries by inhibiting AQP4 and p38 MAPK pathway Pubmed:29758366
Nature and Science of Sleep Chronic treatment with dexamethasone alters clock gene expression and melatonin synthesis in rat pineal gland at night Pubmed:30046256
Journal of Pharmacy and Pharmacology Tannins from fruits attenuates GABA antagonist‐induced anxiety‐like behaviour modulation of neurotransmitters Pubmed: 30198561
Bulletin of Experimental Biology and Medicine Expression of Hif-1α, Nf-κb, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1α, Erythropoietin, VEGF, TGF-β, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia. Corticosterone in … Pubmed: 30353332
Brain, Behavior, and Immunity HMGB1-Mediated Differential Response on Hippocampal Neurotransmitter Disorder and Neuroinflammation in Adolescent Male and Female Mice following Cold Exposure Pubmed: 30476565
Heliyon Establishment and evaluation of a novel mouse model of peri/postmenopausal depression Doi: 10.1016/j.heliyon.2019.e01195
Scientific Reports Mice lacking Casp1, Ifngr and Nos2 genes exhibit altered depressive-and anxiety-like behaviour, and gut microbiome composition Pubmed: 31015500
Food & Function Antidepressant-like effects of dietary gardenia blue pigment derived from genipin and tyrosine Doi: 10.1039/C9FO00480G
Neuroscience Letters Synaptic structure and alterations in the hippocampus in neonatal rats exposed to lipopolysaccharide Pubmed: 31288048
FASEB Journal Contribution of DNA methylation in chronic stress–induced cardiac remodeling and arrhythmias in mice Pubmed: 31431066
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