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Recombinant Topoisomerase II (TOP2)

DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme

  • Product No.RPA792Ra01
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationNucleus
  • Predicted Molecular Mass32.1kDa
  • Accurate Molecular Mass38kDa(Analysis of differences refer to the manual)
  • Residues & TagsGly1079~Ser1328 with N-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder
  • Purity> 80%
  • Isoelectric Point6.1
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 184  US$ 460  US$ 920  US$ 2760  US$ 6900 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in ddH2O to a concentration of 0.1-0.2 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Journal of Experimental & Clinical Cancer Research Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II pubmed:27852319
Bioorganic & Medicinal Chemistry Synthesis of pharmacologically important naphthoquinones and anticancer activity of 2-benzyllawsone through DNA topoisomerase-II inhibition. pubmed:28094224
European Journal of Medicinal Chemistry Antiproliferative activity of diarylnaphthylpyrrolidine derivative via dual target inhibition Pubmed: 31884407
Int J Mol Sci 2-{5-[(Z,2Z)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule Pubmed:35456915
Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
RPA792Ra01 Recombinant Topoisomerase II (TOP2) Positive Control; Immunogen; SDS-PAGE; WB.
PAA792Ra01 Polyclonal Antibody to Topoisomerase II (TOP2) IHC
MAA792Ra21 Monoclonal Antibody to Topoisomerase II (TOP2) WB; IHC; ICC; IP.
SEA792Ra ELISA Kit for Topoisomerase II (TOP2) Enzyme-linked immunosorbent assay for Antigen Detection.
CMA792Ra Multiplex Assay Kit for Topoisomerase II (TOP2) ,etc. by CBA (Cytometric Bead Array) FLIA Kit for Antigen Detection.
LMA792Ra Multiplex Assay Kit for Topoisomerase II (TOP2) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.