Sex Determining Region Y Box Protein 2 (SOX2)

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ANOP3; MCOPS3; SRY-Box 2; Transcription factor SOX-2

Sex Determining Region Y Box Protein 2 (SOX2)
  • Sox2 is one of the key transcription factors required in induced pluripotent stem cells. As forced Oct4 expression induces pluripotency in Sox2-null cells, a group of researchers concluded that the primary role of Sox2 in induced pluripotent stem cells is controlling Oct4 expression, and they perpetuate their own expression when expressed concurrently.The protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in this gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.

  • This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).The ectopic expression of SOX2 may be related to abnormal differentiation of colorectal cancer cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA406Hu01 Recombinant Sex Determining Region Y Box Protein 2 (SOX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA406Hu01 Polyclonal Antibody to Sex Determining Region Y Box Protein 2 (SOX2) WB; IHC; ICC; IP.
MAA406Hu21 Monoclonal Antibody to Sex Determining Region Y Box Protein 2 (SOX2) WB
Assay Kits n/a CLIA Kit for Sex Determining Region Y Box Protein 2 (SOX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sex Determining Region Y Box Protein 2 (SOX2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sex Determining Region Y Box Protein 2 (SOX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sex Determining Region Y Box Protein 2 (SOX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sex Determining Region Y Box Protein 2 (SOX2) Polyclonal Antibody Customized Service Offer
Assay Kits SEA406Mu ELISA Kit for Sex Determining Region Y Box Protein 2 (SOX2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA406Ra01 Recombinant Sex Determining Region Y Box Protein 2 (SOX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA406Ra01 Polyclonal Antibody to Sex Determining Region Y Box Protein 2 (SOX2) WB; IHC; ICC; IP.
MAA406Ra21 Monoclonal Antibody to Sex Determining Region Y Box Protein 2 (SOX2) WB; IHC; ICC; IP.
Assay Kits SEA406Ra ELISA Kit for Sex Determining Region Y Box Protein 2 (SOX2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sex Determining Region Y Box Protein 2 (SOX2) Recombinant Protein Customized Service Offer
Antibodies PAA406Bo01 Polyclonal Antibody to Sex Determining Region Y Box Protein 2 (SOX2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Sex Determining Region Y Box Protein 2 (SOX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sex Determining Region Y Box Protein 2 (SOX2) ELISA Kit Customized Service Offer
  1. "The cDNA sequence and chromosomal location of the human SOX2 gene."Mamm. Genome 5:640-642(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Mutations in SOX2 cause anophthalmia."Nat. Genet. 33:461-463(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Induction of pluripotent stem cells from adult human fibroblasts by defined factors."Cell 131:861-872(2007) [PubMed] [Europe PMC] [Abstract]
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]