Leukemia Inhibitory Factor Receptor (LIFR)

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130.

Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA561Hu02 Recombinant Leukemia Inhibitory Factor Receptor (LIFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA561Hu03 Recombinant Leukemia Inhibitory Factor Receptor (LIFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA561Hu01 Recombinant Leukemia Inhibitory Factor Receptor (LIFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA561Hu02 Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC; IP; FCM
PAA561Hu01 Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC; IP; FCM
PAA561Hu03 Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC/IF
LAA561Hu71 Biotin-Linked Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC.
Assay Kits SEA561Hu ELISA Kit for Leukemia Inhibitory Factor Receptor (LIFR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA561Mu01 Recombinant Leukemia Inhibitory Factor Receptor (LIFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA561Mu02 Recombinant Leukemia Inhibitory Factor Receptor (LIFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA561Mu03 Recombinant Leukemia Inhibitory Factor Receptor (LIFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA561Mu01 Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC; IP.
PAA561Mu03 Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC; IP.
PAA561Mu02 Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC; IP.
LAA561Mu71 Biotin-Linked Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC.
Assay Kits SEA561Mu ELISA Kit for Leukemia Inhibitory Factor Receptor (LIFR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA561Ra01 Recombinant Leukemia Inhibitory Factor Receptor (LIFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA561Ra02 Recombinant Leukemia Inhibitory Factor Receptor (LIFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA561Ra03 Recombinant Leukemia Inhibitory Factor Receptor (LIFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA561Ra01 Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC; IP.
PAA561Ra02 Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC; IP.
PAA561Ra03 Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC; IP.
LAA561Ra71 Biotin-Linked Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Leukemia Inhibitory Factor Receptor (LIFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukemia Inhibitory Factor Receptor (LIFR) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leukemia Inhibitory Factor Receptor (LIFR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leukemia Inhibitory Factor Receptor (LIFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukemia Inhibitory Factor Receptor (LIFR) ELISA Kit Customized Service Offer
  1. "Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130."EMBO J. 10:2839-2848(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter."Oncogene 16:1409-1416(1998) [PubMed] [Europe PMC] [Abstract]
  3. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex."Mol. Cell 31:737-748(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Null leukemia inhibitory factor receptor (LIFR) mutations in Stueve-Wiedemann/Schwartz-Jampel type 2 syndrome."Am. J. Hum. Genet. 74:298-305(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]