Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2)

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CHR-NB2; CHRN-B2; EFNL3; NAChRB2; N-AChR-B2; N-AChRB2; Neuronal Acetylcholine Receptor Beta 2

Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2)

CHRNB2 encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.the CHRNB2 gene comprises 6 exons and spans approximately 9 kb of genomic DNA from the ATG start codon to the TGA stop codon. Exon 1 contains the 5-prime untranslated region, the ATG start codon, and parts of the sequence coding for the putative signal peptide. The hydrophobic transmembrane domains I through III are located in the large exon 5. Exon 6 contains the transmembrane domain IV as well as the translation stop codon and the 3-prime untranslated region. The CHRNB2 introns vary in size from 150 bp (intron 2) to 4.5 kb (intron 5). The splicing at the junctions of CHRNB2 introns 2, 3, and 5 occurred between codons (splicing type 0).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB513Hu01 Recombinant Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB513Hu01 Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) WB; IHC; ICC; IP.
MAB513Hu22 Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) WB; IHC; ICC; IP.
Assay Kits SEB513Hu ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene."Nucleic Acids Res. 18:4272-4272(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)."Hum. Genet. 103:645-653(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes."Mamm. Genome 10:900-905(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
  8. "NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit."Biochim. Biophys. Acta 1798:1608-1614(2010) [PubMed] [Europe PMC] [Abstract]
  9. "NMR structures of the transmembrane domains of the alpha4beta2 nAChR."Biochim. Biophys. Acta 1818:1261-1268(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The nicotinic receptor beta-2 subunit is mutant in nocturnal frontal lobe epilepsy."Nat. Genet. 26:275-276(2000) [PubMed] [Europe PMC] [Abstract]
  11. "CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy."Am. J. Hum. Genet. 68:225-231(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2)."Nicotine Tob. Res. 4:115-125(2002) [PubMed] [Europe PMC] [Abstract]