Cytokeratin 17 (CK17)

[Edit]

PC2; KRT17; K17; PC; PCHC1; Keratin 17; Keratin, type I cytoskeletal 17

Cytokeratin 17 (CK17)

Keratin 17 is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.The functional KRT17 gene differs from the pseudogenes by the extent of methylation of certain DNA sequences in the 5-prime upstream region. The KRT17 gene encodes a polypeptide of 432 amino acids with a calculated molecular weight of 48,000. Using S1-nuclease protection assays and RNAs from several cell lines, Troyanovsky et al. identified a single transcriptional start point 26 nucleotides downstream from a TATA box element. Synthesis of cytokeratin-17 seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cell.'

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB822Hu01 Recombinant Cytokeratin 17 (CK17) Positive Control; Immunogen; SDS-PAGE; WB.
RPB822Hu02 Recombinant Cytokeratin 17 (CK17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB822Hu01 Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP; FCM
MAB822Hu22 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
LAB822Hu71 Biotin-Linked Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC.
LAB822Hu81 FITC-Linked Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IF.
MAB822Hu21 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
MAB822Hu23 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
MAB822Hu24 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
MAB822Hu25 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
MAB822Hu27 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
PAB822Hu02 Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
Assay Kits SEB822Hu ELISA Kit for Cytokeratin 17 (CK17) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytokeratin 17 (CK17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytokeratin 17 (CK17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytokeratin 17 (CK17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytokeratin 17 (CK17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 17 (CK17) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB822Ra01 Recombinant Cytokeratin 17 (CK17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB822Ra01 Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
LAB822Ra71 Biotin-Linked Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cytokeratin 17 (CK17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 17 (CK17) ELISA Kit Customized Service Offer
  1. "Characterization of the human gene encoding cytokeratin 17 and its expression pattern."Eur. J. Cell Biol. 59:127-137(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Interferon-gamma regulates expression of a novel keratin class I gene."Eur. J. Immunol. 22:975-979(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Keratin 16 and keratin 17 mutations cause pachyonychia congenita."Nat. Genet. 9:273-278(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Patterns of expression of keratin 17 in human epithelia: dependency on cell position."J. Cell Sci. 93:419-426(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Keratin expression in the normal nail unit: markers of regional differentiation."Br. J. Dermatol. 142:89-96(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype."J. Invest. Dermatol. 114:1101-1107(2000) [PubMed] [Europe PMC] [Abstract]
  10. "HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis."J. Dermatol. Sci. 38:25-39(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Interferon-gamma-dependent in vitro model for the putative keratin 17 autoimmune loop in psoriasis: exploration of pharmaco- and gene-therapeutic effects."Skin Pharmacol. Physiol. 18:42-54(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis."J. Am. Acad. Dermatol. 54:992-1002(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion."J. Biol. Chem. 286:42403-42413(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex."J. Invest. Dermatol. 108:220-223(1997) [PubMed] [Europe PMC] [Abstract]
  20. "Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2."Br. J. Dermatol. 139:475-480(1998) [PubMed] [Europe PMC] [Abstract]
  21. "Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2."J. Invest. Dermatol. 113:848-850(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Novel keratin 17 mutations in pachyonychia congenita type 2."J. Invest. Dermatol. 116:806-808(2001) [PubMed] [Europe PMC] [Abstract]
  23. "Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita."J. Invest. Dermatol. 117:1391-1396(2001) [PubMed] [Europe PMC] [Abstract]
  24. "A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2."J. Invest. Dermatol. 118:545-547(2002) [PubMed] [Europe PMC] [Abstract]
  25. "A novel mutation in the second half of the keratin 17 1A domain in a large pedigree with delayed-onset pachyonychia congenita type 2."J. Invest. Dermatol. 122:892-895(2004) [PubMed] [Europe PMC] [Abstract]
  26. "Identification of a recurrent mutation in keratin 17 in a Japanese family with pachyonychia congenita type 2."J. Dermatol. Sci. 38:60-63(2005) [PubMed] [Europe PMC] [Abstract]
  27. "The genetic basis of pachyonychia congenita."J. Investig. Dermatol. Symp. Proc. 10:21-30(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Keratin 17 mutation in pachyonychia congenita type 2 patient with early onset steatocystoma multiplex and Hutchinson-like tooth deformity."J. Dermatol. 33:161-164(2006) [PubMed] [Europe PMC] [Abstract]
  29. "A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita."J. Dermatol. Sci. 48:199-205(2007) [PubMed] [Europe PMC] [Abstract]
  30. "A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb."Br. J. Dermatol. 159:730-732(2008) [PubMed] [Europe PMC] [Abstract]
  31. "Novel missense mutation of keratin in Chinese family with steatocystoma multiplex."J. Eur. Acad. Dermatol. Venereol. 23:723-724(2009) [PubMed] [Europe PMC] [Abstract]
  32. "A large mutational study in pachyonychia congenita."J. Invest. Dermatol. 131:1018-1024(2011) [PubMed] [Europe PMC] [Abstract]
  33. "A novel mutation of keratin 17 gene in a pedigree with pachyonychia congenita type 2."Int. J. Dermatol. 52:117-119(2013) [PubMed] [Europe PMC] [Abstract]
  34. "Novel mutation (p.L91P, c.272T>C) of keratin 17 in a case with pachyonychia congenita type 2."J. Dermatol. 40:757-758(2013) [PubMed] [Europe PMC] [Abstract]