Vascular Endothelial Growth Factor 121 (VEGF121)

is a VEGF form that does not bind to neuropilins. Surprisingly, both np1 and neuropilin-2 (np2) enhanced VEGF121-induced phosphorylation of VEGFR-2 and VEGF121-induced proliferation of endothelial cells. The enhancement of VEGF121 activity by np1 was accompanied by a 10-fold increase in binding affinity to VEGFR-2 and was not associated with the formation of new VEGFR-2/np1 complexes. These observations suggest that neuropilins enhance the activity of VEGF forms that do not bind to neuropilins, indicate that np2 is a functional VEGF receptor, and imply that spontaneously formed VEGFR-2/np1 complexes suffice for efficient neuropilin mediated enhancement of VEGF activity.—Shraga-Heled, N., Kessler, O., Prahst, C., Kroll, J., Augustin, H., Neufeld, G. Neuropilin-1 and neuropilin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB851Hu01 Recombinant Vascular Endothelial Growth Factor 121 (VEGF121) Positive Control; Immunogen; SDS-PAGE; WB.
RPB851Hu02 Recombinant Vascular Endothelial Growth Factor 121 (VEGF121) Positive Control; Immunogen; SDS-PAGE; WB.
APB851Hu01 Active Vascular Endothelial Growth Factor 121 (VEGF121) Cell culture; Activity Assays.
Antibodies PAB851Hu01 Polyclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) ICC/IF
PAB851Hu02 Polyclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) WB; IHC; ICC; IP.
LAB851Hu71 Biotin-Linked Polyclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) WB; IHC; ICC.
MAB851Hu21 Monoclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) IHC
MAB851Hu22 Monoclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) IHC
MAB851Hu23 Monoclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) IHC
MAB851Hu24 Monoclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) IHC
MAB851Hu25 Monoclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) WB; IHC; ICC/IF
MAB851Hu27 Monoclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) IHC
Assay Kits SEB851Hu ELISA Kit for Vascular Endothelial Growth Factor 121 (VEGF121) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB851Mu01 Recombinant Vascular Endothelial Growth Factor 121 (VEGF121) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB851Mu01 Polyclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) WB; IHC; ICC; IP.
Assay Kits SEB851Mu ELISA Kit for Vascular Endothelial Growth Factor 121 (VEGF121) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Vascular Endothelial Growth Factor 121 (VEGF121) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) Polyclonal Antibody Customized Service Offer
Assay Kits SEB851Ra ELISA Kit for Vascular Endothelial Growth Factor 121 (VEGF121) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB851Fi01 Recombinant Vascular Endothelial Growth Factor 121 (VEGF121) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vascular Endothelial Growth Factor 121 (VEGF121) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vascular Endothelial Growth Factor 121 (VEGF121) ELISA Kit Customized Service Offer