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Zyxin (ZYX)

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ESP2; HED2

Zyxin (ZYX)
CCC C235
HGNC 13200
MGI 103072
PubMed 10831611
RGD 620698
UniProt Q15942
Wiki Zyxin

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC235Hu01 Recombinant Zyxin (ZYX) Positive Control; Immunogen; SDS-PAGE; WB.
RPC235Hu02 Recombinant Zyxin (ZYX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC235Hu01 Polyclonal Antibody to Zyxin (ZYX) WB,IHC
PAC235Hu02 Polyclonal Antibody to Zyxin (ZYX) WB
LAC235Hu71 Biotin-Linked Polyclonal Antibody to Zyxin (ZYX) WB
LAC235Hu81 FITC-Linked Polyclonal Antibody to Zyxin (ZYX) WB; IHC; ICC; IF.
MAC235Hu21 Monoclonal Antibody to Zyxin (ZYX) WB
MAC235Hu25 Monoclonal Antibody to Zyxin (ZYX) WB
MAC235Hu26 Monoclonal Antibody to Zyxin (ZYX) WB
MAC235Hu22 Monoclonal Antibody to Zyxin (ZYX) WB
Assay Kits SEC235Hu ELISA Kit for Zyxin (ZYX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zyxin (ZYX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zyxin (ZYX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zyxin (ZYX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zyxin (ZYX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zyxin (ZYX) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zyxin (ZYX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zyxin (ZYX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zyxin (ZYX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zyxin (ZYX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zyxin (ZYX) ELISA Kit Customized Service Offer
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  7. , Submitted (FEB-2008) to UniProtKB
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  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
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  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]